Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1 alpha Stabilization and Expression of Its Downstream Targets

Marike W. van Gisbergen, Kelly Offermans, An M. Voets, Natasja G. Lieuwes, Rianne Biemans, Roland F. Hoffmann, Ludwig J. Dubois*, Philippe Lambin

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number770
Number of pages12
JournalFrontiers in Oncology
Volume10
DOIs
Publication statusPublished - 19 May 2020

Keywords

  • mtDNA
  • mitochondria
  • OXPHOS
  • CAIX
  • HIF-1 alpha
  • Metformin
  • OXIDATIVE STRESS
  • COMPLEX I
  • METFORMIN
  • CANCER
  • CELLS
  • HIF-1
  • GENE
  • HETEROGENEITY
  • SIRT3
  • ROS

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