Mitochondrial dynamics, quality control and miRNA regulation in skeletal muscle: implications for obesity and related metabolic disease

Dennis Dahlmans, Alexandre Houzelle, Patrick Schrauwen, Joris Hoeks*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

The western dietary habits and sedentary lifestyle largely contributes to the growing epidemic of obesity. Mitochondria are at the front line of cellular energy homoeostasis and are implicated in the pathophysiology of obesity and obesity-related metabolic disease. In recent years, novel aspects in the regulation of mitochondrial metabolism, such as mitochondrial dynamics, mitochondrial protein quality control and post-transcriptional regulation of genes coding for mitochondrial proteins, have emerged. In this review, we discuss the recent findings concerning the dysregulation of these processes in skeletal muscle in obesogenic conditions.
Original languageEnglish
Pages (from-to)843-852
JournalClinical Science
Volume130
Issue number11
DOIs
Publication statusPublished - 1 Jun 2016

Keywords

  • metabolic disease
  • microRNAs
  • mitochondria
  • obesity
  • skeletal muscle

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