Mirror-symmetric tonotopic maps in human primary auditory cortex

Elia Formisano, Dae-Shik Kim, Francesco Di Salle, P.F. van de Moortele, Kamil Ugurbil, Rainer Goebel*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

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    Abstract

    Understanding the functional organization of the human primary auditory cortex (PAC) is an essential step in elucidating the neural mechanisms underlying the perception of sound, including speech and music. Based on invasive research in animals, it is believed that neurons in human PAC that respond selectively with respect to the spectral content of a sound form one or more maps in which neighboring patches on the cortical surface respond to similar frequencies (tonotopic maps). The number and the cortical layout of such tonotopic maps in the human brain, however, remain unknown. Here we use silent, event-related functional magnetic resonance imaging at 7 Tesla and a cortex-based analysis of functional data to delineate with high spatial resolution the detailed topography of two tonotopic maps in two adjacent subdivisions of PAC. These maps share a low-frequency border, are mirror symmetric, and clearly resemble those of presumably homologous fields in the macaque monkey.
    Original languageEnglish
    Pages (from-to)859-869
    JournalNeuron
    Volume40
    Issue number4
    DOIs
    Publication statusPublished - 2003

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