miRNAs Related to Skeletal Diseases

Claudine Seeliger, Elizabeth R Balmayor, Martijn van Griensven*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

miRNAs as non-coding, short, double-stranded RNA segments are important for cellular biological functions, such as proliferation, differentiation, and apoptosis. miRNAs mainly contribute to the inhibition of important protein translations through their cleavage or direct repression of target messenger RNAs expressions. In the last decade, miRNAs got in the focus of interest with new publications on miRNAs in the context of different diseases. For many types of cancer or myocardial damage, typical signatures of local or systemically circulating miRNAs have already been described. However, little is known about miRNA expressions and their molecular effect in skeletal diseases. An overview of published studies reporting miRNAs detection linked with skeletal diseases was conducted. All regulated miRNAs were summarized and their molecular interactions were illustrated. This review summarizes the involvement and interaction of miRNAs in different skeletal diseases. Thereby, 59 miRNAs were described to be deregulated in tissue, cells, or in the circulation of osteoarthritis (OA), 23 miRNAs deregulated in osteoporosis, and 107 miRNAs deregulated in osteosarcoma (OS). The molecular influences of miRNAs regarding OA, osteoporosis, and OS were illustrated. Specific miRNA signatures for skeletal diseases are described in the literature. Some overlapped, but also unique ones for each disease exist. These miRNAs may present useful targets for the development of new therapeutic approaches and are candidates for diagnostic evaluations.

Original languageEnglish
Pages (from-to)1261-1281
Number of pages21
JournalStem Cells and Development
Volume25
Issue number17
DOIs
Publication statusPublished - 1 Sep 2016
Externally publishedYes

Keywords

  • Animals
  • Apoptosis/genetics
  • Bone Diseases/genetics
  • Humans
  • MicroRNAs/genetics
  • Osteogenesis/genetics
  • Regeneration/genetics
  • Transcription Factors/metabolism
  • CIRCULATING MICRORNAS
  • DOWN-REGULATION
  • REGULATES CHONDROGENIC DIFFERENTIATION
  • MESENCHYMAL STEM-CELLS
  • PRE-OSTEOBLAST DIFFERENTIATION
  • ARTICLE. SEE APRIL
  • FATTY-ACID SYNTHASE
  • MICRORNA EXPRESSION
  • OSTEOSARCOMA TUMOR-GROWTH
  • SUPPRESSES OSTEOGENIC DIFFERENTIATION

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