MiR423-5p As a Circulating Biomarker for Heart Failure

Anke J. Tijsen, Esther E. Creemers, Perry D Moerland, Leon J. de Windt, Allard C. van der Wal, Wouter E. Kok, Yigal M. Pinto*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

476 Citations (Web of Science)


Rationale: Aberrant expression profiles of circulating microRNAs (miRNAs) have been described in various diseases and provide high sensitivity and specificity. We explored circulating miRNAs as potential biomarkers in patients with heart failure (HF). Objective: The goal of this study was to determine whether miRNAs allow to distinguish clinical HF not only from healthy controls but also from non-HF forms of dyspnea. Methods and Results: A miRNA array was performed on plasma of 12 healthy controls and 12 HF patients. From this array, we selected 16 miRNAs for a second clinical study in 39 healthy controls and in 50 cases with reports of dyspnea, of whom 30 were diagnosed with HF and 20 were diagnosed with dyspnea attributable to non-HF-related causes. This revealed that miR423-5p was specifically enriched in blood of HF cases and receiver-operator-characteristics (ROC) curve analysis showed miR423-5p to be a diagnostic predictor of HF, with an area under the curve of 0.91 (P
Original languageEnglish
Pages (from-to)1035-U63
JournalCirculation Research
Issue number6
Publication statusPublished - 2 Apr 2010


  • MicroRNAs
  • plasma
  • heart failure
  • biomarker

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