MIPs for commercial application in low-cost sensors and assays - An overview of the current status quo

Joseph W Lowdon, Hanne Diliën, Pankaj Singla, Marloes Peeters, Thomas J Cleij, Bart van Grinsven, Kasper Eersels*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

55 Citations (Web of Science)

Abstract

Molecularly imprinted polymers (MIPs) have emerged over the past few decades as interesting synthetic alternatives due to their long-term chemical and physical stability and low-cost synthesis procedure. They have been integrated into many sensing platforms and assay formats for the detection of various targets, ranging from small molecules to macromolecular entities such as pathogens and whole cells. Despite the advantages MIPs have over natural receptors in terms of commercialization, the striking success stories of biosensor applications such as the glucose meter or the self-test for pregnancy have not been matched by MIP-based sensor or detection kits yet. In this review, we zoom in on the commercial potential of MIP technology and aim to summarize the latest developments in their commercialization and integration into sensors and assays with high commercial potential. We will also analyze which bottlenecks are inflicting with commercialization and how recent advances in commercial MIP synthesis could overcome these obstacles in order for MIPs to truly achieve their commercial potential in the near future.

Original languageEnglish
Article number128973
Pages (from-to)128973
Number of pages19
JournalSensors and Actuators B-Chemical
Volume325
DOIs
Publication statusPublished - 15 Dec 2020

Keywords

  • Molecularly imprinted polymers
  • Diagnostics
  • Biosensing
  • Lateral flow assays
  • Commercialization
  • MOLECULARLY IMPRINTED POLYMER
  • SURFACE-PLASMON RESONANCE
  • QUARTZ-CRYSTAL MICROBALANCE
  • SOLID-PHASE SYNTHESIS
  • LABEL-FREE DETECTION
  • HEAT-TRANSFER RESISTANCE
  • HIGH-DENSITY-LIPOPROTEIN
  • ZNS QUANTUM DOTS
  • ELECTROCHEMICAL SENSOR
  • THERMAL DETECTION

Cite this