Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Thery, Kenneth W. Witwer, Elena Aikawa, Maria Jose Alcaraz, Johnathon D. Anderson, Ramaroson Andriantsitohaina, Anna Antoniou, Tanina Arab, Fabienne Archer, Georgia K. Atkin-Smith, D. Craig Ayre, Jean-Marie Bach, Daniel Bachurski, Hossein Baharvand, Leonora Balaj, Shawn Baldacchino, Natalie N. Bauer, Amy A. Baxter, Mary Bebawy, Carla BeckhamApolonija Bedina Zavec, Abderrahim Benmoussa, Anna C. Berardi, Paolo Bergese, Ewa Bielska, Cherie Blenkiron, Sylwia Bobis-Wozowicz, Eric Boilard, Wilfrid Boireau, Antonella Bongiovanni, Francesc E. Borras, Steffi Bosch, Chantal M. Boulanger, Xandra Breakefield, Andrew M. Breglio, Meadhbh A. Brennan, David R. Brigstock, Alain Brisson, Marike L. D. Broekman, Jacqueline F. Bromberg, Paulina Bryl-Gorecka, Shilpa Buch, Amy H. Buck, Dylan Burger, Sara Busatto, Dominik Buschmann, Benedetta Bussolati, Edit Buzas, James Bryan Byrd, Giovanni Camussi, David R. F. Carter, Sarah Caruso, Lawrence W. Chamley, Yu-Ting Chang, Chihchen Chen, Shuai Chen, Lesley Cheng, Andrew R. Chin, Aled Clayton, Stefano P. Clerici, Alex Cocks, Emanuele Cocucci, Robert J. Coffey, Anabela Cordeiro-da-Silva, Yvonne Couch, Frank A. W. Coumans, Beth Coyle, Rossella Crescitelli, Miria Ferreira Criado, Crislyn D'Souza-Schorey, Saumya Das, Amrita Datta Chaudhuri, Paola de Candia, Eliezer F. De Santana Junior, Olivier De Wever, Hernando A. del Portillo, Tanguy Demaret, Sarah Deville, Andrew Devitt, Bert Dhondt, Dolores Di Vizio, Lothar C. Dieterich, Vincenza Dolo, Ana Paula Dominguez Rubio, Massimo Dominici, Mauricio R. Dourado, Tom A. P. Driedonks, Filipe Duarte, Heather M. Duncan, Ramon M. Eichenberger, Karin Ekstrom, Samir E. L. Andaloussi, Celine Elie-Caille, Uta Erdbrugger, Juan M. Falcon-Perez, Farah Fatima, Jason E. Fish, Miguel Flores-Bellver, Andras Forsonits, Annie Frelet-Barrand, Fabia Fricke, Gregor Fuhrmann, Susanne Gabrielsson, Ana Gamez-Valero, Chris Gardiner, Kathrin Gaertner, Raphael Gaudin, Yong Song Gho, Bernd Giebel, Caroline Gilbert, Mario Gimona, Ilaria Giusti, Deborah C. Goberdhan, Andre Goergens, Sharon M. Gorski, David W. Greening, Julia Christina Gross, Alice Gualerzi, Gopal N. Gupta, Dakota Gustafson, Aase Handberg, Reka A. Haraszti, Paul Harrison, Hargita Hegyesi, An Hendrix, Andrew F. Hill, Fred H. Hochberg, Karl F. Hoffmann, Beth Holder, Harry Holthofer, Baharak Hosseinkhani, Guoku Hu, Yiyao Huang, Veronica Huber, Stuart Hunt, Ahmed Gamal-Eldin Ibrahim, Tsuneya Ikezu, Jameel M. Inal, Mustafa Isin, Alena Ivanova, Hannah K. Jackson, Soren Jacobsen, Steven M. Jay, Muthuvel Jayachandran, Guido Jenster, Lanzhou Jiang, Suzanne M. Johnson, Jennifer C. Jones, Ambrose Jong, Tijana Jovanovic-Talisman, Stephanie Jung, Raghu Kalluri, Shin-ichi Kano, Sukhbir Kaur, Yumi Kawamura, Evan T. Keller, Delaram Khamari, Elena Khomyakova, Anastasia Khvorova, Peter Kierulf, Kwang Pyo Kim, Thomas Kislinger, Mikael Klingeborn, David J. Klinke, Miroslaw Kornek, Maja M. Kosanovic, Arpad Ferenc Kovacs, Eva-Maria Kraemer-Albers, Susanne Krasemann, Mirja Krause, Igor Kurochkin, Gina D. Kusuma, Soren Kuypers, Saara Laitinen, Scott M. Langevin, Lucia R. Languino, Joanne Lannigan, Cecilia Lasser, Louise C. Laurent, Gregory Lavieu, Elisa Lazaro-Ibanez, Soazig Le Lay, Myung-Shin Lee, Yi Xin Fiona Lee, Debora S. Lemos, Metka Lenassi, Aleksandra Leszczynska, Isaac T. S. Li, Ke Liao, Sten F. Libregts, Erzsebet Ligeti, Rebecca Lim, Sai Kiang Lim, Aija Line, Karen Linnemannstoens, Alicia Llorente, Catherine A. Lombard, Magdalena J. Lorenowicz, Akos M. Lorincz, Jan Lotvall, Jason Lovett, Michelle C. Lowry, Xavier Loyer, Quan Lu, Barbara Lukomska, Taral R. Lunavat, Sybren L. N. Maas, Harmeet Malhi, Antonio Marcilla, Jacopo Mariani, Javier Mariscal, Elena S. Martens-Uzunova, Lorena Martin-Jaular, M. Carmen Martinez, Vilma Regina Martins, Mathilde Mathieu, Suresh Mathivanan, Marco Maugeri, Lynda K. McGinnis, Mark J. McVey, David G. Meckes, Katie L. Meehan, Inge Mertens, Valentina R. Minciacchi, Andreas Moller, Malene Moller Jorgensen, Aizea Morales-Kastresana, Jess Morhayim, Francois Mullier, Maurizio Muraca, Luca Musante, Veronika Mussack, Dillon C. Muth, Kathryn H. Myburgh, Tanbir Najrana, Muhammad Nawaz, Irina Nazarenko, Peter Nejsum, Christian Neri, Tommaso Neri, Rienk Nieuwland, Leonardo Nimrichter, John P. Nolan, Esther N. M. Nolte-'t Hoen, Nicole Noren Hooten, Lorraine O'Driscoll, Tina O'Grady, Ana O'Loghlen, Takahiro Ochiya, Martin Olivier, Alberto Ortiz, Luis A. Ortiz, Xabier Osteikoetxea, Ole Ostegaard, Matias Ostrowski, Jaesung Park, D. Michiel Pegtel, Hector Peinado, Francesca Perut, Michael W. Pfaffl, Donald G. Phinney, Bartijn C. H. Pieters, Ryan C. Pink, David S. Pisetsky, Elke Pogge von Strandmann, Iva Polakovicova, Ivan K. H. Poon, Bonita H. Powell, Ilaria Prada, Lynn Pulliam, Peter Quesenberry, Annalisa Radeghieri, Robert L. Raffai, Stefania Raimondo, Janusz Rak, Marcel Ramirez, Graca Raposo, Morsi S. Rayyan, Neta Regev-Rudzki, Franz L. Ricklefs, Paul D. Robbins, David D. Roberts, Silvia C. Rodrigues, Eva Rohde, Sophie Rome, Kasper M. A. Rouschop, Aurelia Rughetti, Ashley E. Russell, Paula Saa, Susmita Sahoo, Edison Salas-Huenuleo, Catherine Sanchez, Julie A. Saugstad, Meike J. Saul, Raymond M. Schiffelers, Raphael Schneider, Tine Hiorth Schoyen, Aaron Scott, Eriomina Shahaj, Shivani Sharma, Olga Shatnyeva, Faezeh Shekari, Ganesh Vilas Shelke, Ashok K. Shetty, Kiyotaka Shiba, Pia R-M Siljander, Andreia M. Silva, Agata Skowronek, Orman L. Snyder, Rodrigo Pedro Soares, Barbara W. Sodar, Carolina Soekmadji, Javier Sotillo, Philip D. Stahl, Willem Stoorvogel, Shannon L. Stott, Erwin F. Strasser, Simon Swift, Hidetoshi Tahara, Muneesh Tewari, Kate Timms, Swasti Tiwari, Rochelle Tixeira, Mercedes Tkach, Wei Seong Toh, Richard Tomasini, Ana Claudia Torrecilhas, Juan Pablo Tosar, Vasilis Toxavidis, Lorena Urbanelli, Pieter Vader, Bas W. M. van Balkom, Susanne G. van der Grein, Jan Van Deun, Martijn J. C. van Herwijnen, Kendall Van Keuren-Jensen, Guillaume van Niel, Martin E. van Royen, Andre J. van Wijnen, M. Helena Vasconcelos, Ivan J. Vechetti, Tiago D. Veit, Laura J. Vella, Emilie Velot, Frederik J. Verweij, Beate Vestad, Jose L. Vinas, Tamas Visnovitz, Krisztina V. Vukman, Jessica Wahlgren, Dionysios C. Watson, Marca H. M. Wauben, Alissa Weaver, Jason P. Webber, Viktoria Weber, Ann M. Wehman, Daniel J. Weiss, Joshua A. Welsh, Sebastian Wendt, Asa M. Wheelock, Zoltan Wiener, Leonie Witte, Joy Wolfram, Angeliki Xagorari, Patricia Xander, Jing Xu, Xiaomei Yan, Maria Yanez-Mo, Hang Yin, Yuana Yuana, Valentina Zappulli, Jana Zarubova, Vytautas Zekas, Jian-ye Zhang, Zezhou Zhao, Lei Zheng, Alexander R. Zheutlin, Antje M. Zickler, Pascale Zimmermann, Angela M. Zivkovic, Davide Zocco, Ewa K. Zuba-Surma

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number1535750
Number of pages43
JournalJournal of Extracellular Vesicles
Volume7
Issue number1
DOIs
Publication statusPublished - 23 Nov 2018

Keywords

  • extracellular vesicles
  • exosomes
  • ectosomes
  • microvesicles
  • minimal information requirements
  • guidelines
  • standardization
  • microparticles
  • rigor
  • reproducibility
  • CELL-DERIVED MICROPARTICLES
  • SURFACE-PLASMON RESONANCE
  • SIZE-EXCLUSION CHROMATOGRAPHY
  • FIELD-FLOW FRACTIONATION
  • HUMAN URINARY EXOSOMES
  • PROSTATE-CANCER
  • MEMBRANE-VESICLES
  • FETAL BOVINE
  • CIRCULATING MICROPARTICLES
  • PREANALYTICAL PARAMETERS

Cite this

Thery, C., Witwer, K. W., Aikawa, E., Jose Alcaraz, M., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin-Smith, G. K., Ayre, D. C., Bach, J-M., Bachurski, D., Baharvand, H., Balaj, L., Baldacchino, S., Bauer, N. N., Baxter, A. A., Bebawy, M., ... Zuba-Surma, E. K. (2018). Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. Journal of Extracellular Vesicles , 7(1), [1535750]. https://doi.org/10.1080/20013078.2018.1535750