Mindfulness-based cognitive therapy severely fatigued multiple sclerosis patients: A waiting list controlled study

Alexandra E W Hoogerwerf, Yvonne Bol, Jill Lobbestael, Raymond Hupperts, Caroline M. van Heugten

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: Fatigue is the most common symptom in multiple sclerosis. Evidence-based treatment options are scarce.

OBJECTIVE: To study the feasibility and potential effectiveness of mindfulness-based cognitive therapy in severely fatigued multiple sclerosis patients.

METHODS: Non-randomized pilot study with a wai-ting list control period including 59 multiple sclerosis patients with severe fatigue.

PRIMARY OUTCOME MEASURE: fatigue severity subscale of the Checklist Individual Strength-20. Secondary measures: Hospital Anxiety and Depression Scale, Life Satisfaction Questionnaire, subscale sleep of the Symptom Checklist-90, Cognitive Failure Questionnaire, Fatigue Catastrophizing Scale, Coping Inventory of Stressful Situations, and Five Facet Mindfulness Questionnaire-Short Form. Measurements were taken before treatment (double baseline), after treatment, and at follow-up (3 months).

RESULTS: Adherence rate was 71%. Eight out of 10 participants who completed the intervention were satisfied with the intervention. Significant time effects were found for 7 out of 11 outcome measures (p = 0.006 to < 0.001). The effect size was moderate for all outcome measures that were significant post-treatment and/or at follow-up (Ƞ² = 0.10-0.17). Improvements were maintained at follow-up. Of the completers, 46% showed a clinically relevant change regarding fatigue.

CONCLUSION: Mindfulness-based cognitive therapy is feasible in severely fatigued multiple sclerosis patients and has positive results in the reduction of severe fatigue and several psychological factors.

Original languageEnglish
Pages (from-to)497–504
Number of pages8
JournalJournal of Rehabilitation Medicine
Volume49
Issue number6
DOIs
Publication statusPublished - 8 Jun 2017

Keywords

  • Journal Article
  • DEPRESSION SCALE
  • BEHAVIOR THERAPY
  • multiple sclerosis
  • mindfulness
  • MS
  • VALIDATION
  • HOSPITAL ANXIETY
  • mindfulness-based cognitive therapy
  • RANDOMIZED CONTROLLED-TRIAL
  • CANCER
  • IMPAIRMENT
  • fatigue
  • QUALITY-OF-LIFE

Cite this

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title = "Mindfulness-based cognitive therapy severely fatigued multiple sclerosis patients: A waiting list controlled study",
abstract = "BACKGROUND: Fatigue is the most common symptom in multiple sclerosis. Evidence-based treatment options are scarce.OBJECTIVE: To study the feasibility and potential effectiveness of mindfulness-based cognitive therapy in severely fatigued multiple sclerosis patients.METHODS: Non-randomized pilot study with a wai-ting list control period including 59 multiple sclerosis patients with severe fatigue.PRIMARY OUTCOME MEASURE: fatigue severity subscale of the Checklist Individual Strength-20. Secondary measures: Hospital Anxiety and Depression Scale, Life Satisfaction Questionnaire, subscale sleep of the Symptom Checklist-90, Cognitive Failure Questionnaire, Fatigue Catastrophizing Scale, Coping Inventory of Stressful Situations, and Five Facet Mindfulness Questionnaire-Short Form. Measurements were taken before treatment (double baseline), after treatment, and at follow-up (3 months).RESULTS: Adherence rate was 71{\%}. Eight out of 10 participants who completed the intervention were satisfied with the intervention. Significant time effects were found for 7 out of 11 outcome measures (p = 0.006 to < 0.001). The effect size was moderate for all outcome measures that were significant post-treatment and/or at follow-up (Ƞ² = 0.10-0.17). Improvements were maintained at follow-up. Of the completers, 46{\%} showed a clinically relevant change regarding fatigue.CONCLUSION: Mindfulness-based cognitive therapy is feasible in severely fatigued multiple sclerosis patients and has positive results in the reduction of severe fatigue and several psychological factors.",
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author = "Hoogerwerf, {Alexandra E W} and Yvonne Bol and Jill Lobbestael and Raymond Hupperts and {van Heugten}, {Caroline M.}",
year = "2017",
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language = "English",
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Mindfulness-based cognitive therapy severely fatigued multiple sclerosis patients : A waiting list controlled study. / Hoogerwerf, Alexandra E W; Bol, Yvonne; Lobbestael, Jill; Hupperts, Raymond; van Heugten, Caroline M.

In: Journal of Rehabilitation Medicine, Vol. 49, No. 6, 08.06.2017, p. 497–504.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Mindfulness-based cognitive therapy severely fatigued multiple sclerosis patients

T2 - A waiting list controlled study

AU - Hoogerwerf, Alexandra E W

AU - Bol, Yvonne

AU - Lobbestael, Jill

AU - Hupperts, Raymond

AU - van Heugten, Caroline M.

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N2 - BACKGROUND: Fatigue is the most common symptom in multiple sclerosis. Evidence-based treatment options are scarce.OBJECTIVE: To study the feasibility and potential effectiveness of mindfulness-based cognitive therapy in severely fatigued multiple sclerosis patients.METHODS: Non-randomized pilot study with a wai-ting list control period including 59 multiple sclerosis patients with severe fatigue.PRIMARY OUTCOME MEASURE: fatigue severity subscale of the Checklist Individual Strength-20. Secondary measures: Hospital Anxiety and Depression Scale, Life Satisfaction Questionnaire, subscale sleep of the Symptom Checklist-90, Cognitive Failure Questionnaire, Fatigue Catastrophizing Scale, Coping Inventory of Stressful Situations, and Five Facet Mindfulness Questionnaire-Short Form. Measurements were taken before treatment (double baseline), after treatment, and at follow-up (3 months).RESULTS: Adherence rate was 71%. Eight out of 10 participants who completed the intervention were satisfied with the intervention. Significant time effects were found for 7 out of 11 outcome measures (p = 0.006 to < 0.001). The effect size was moderate for all outcome measures that were significant post-treatment and/or at follow-up (Ƞ² = 0.10-0.17). Improvements were maintained at follow-up. Of the completers, 46% showed a clinically relevant change regarding fatigue.CONCLUSION: Mindfulness-based cognitive therapy is feasible in severely fatigued multiple sclerosis patients and has positive results in the reduction of severe fatigue and several psychological factors.

AB - BACKGROUND: Fatigue is the most common symptom in multiple sclerosis. Evidence-based treatment options are scarce.OBJECTIVE: To study the feasibility and potential effectiveness of mindfulness-based cognitive therapy in severely fatigued multiple sclerosis patients.METHODS: Non-randomized pilot study with a wai-ting list control period including 59 multiple sclerosis patients with severe fatigue.PRIMARY OUTCOME MEASURE: fatigue severity subscale of the Checklist Individual Strength-20. Secondary measures: Hospital Anxiety and Depression Scale, Life Satisfaction Questionnaire, subscale sleep of the Symptom Checklist-90, Cognitive Failure Questionnaire, Fatigue Catastrophizing Scale, Coping Inventory of Stressful Situations, and Five Facet Mindfulness Questionnaire-Short Form. Measurements were taken before treatment (double baseline), after treatment, and at follow-up (3 months).RESULTS: Adherence rate was 71%. Eight out of 10 participants who completed the intervention were satisfied with the intervention. Significant time effects were found for 7 out of 11 outcome measures (p = 0.006 to < 0.001). The effect size was moderate for all outcome measures that were significant post-treatment and/or at follow-up (Ƞ² = 0.10-0.17). Improvements were maintained at follow-up. Of the completers, 46% showed a clinically relevant change regarding fatigue.CONCLUSION: Mindfulness-based cognitive therapy is feasible in severely fatigued multiple sclerosis patients and has positive results in the reduction of severe fatigue and several psychological factors.

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KW - VALIDATION

KW - HOSPITAL ANXIETY

KW - mindfulness-based cognitive therapy

KW - RANDOMIZED CONTROLLED-TRIAL

KW - CANCER

KW - IMPAIRMENT

KW - fatigue

KW - QUALITY-OF-LIFE

U2 - 10.2340/16501977-2237

DO - 10.2340/16501977-2237

M3 - Article

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VL - 49

SP - 497

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JO - Journal of Rehabilitation Medicine

JF - Journal of Rehabilitation Medicine

SN - 1650-1977

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