Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms

Sara Botschuijver; Sophie A. van Diest; Isabelle A. M. van Thiel; Rafael S. Saia; Anne S. Strik; Zhumei Yu; Daniele Maria-Ferreira; Olaf Welting; Daniel Keszthelyi; Gary Jennings; Sigrid E. M. Heinsbroek; Ronald P. Oude Elferink; Frank H. J. Schuren; Wouter J. de Jonge; Rene M. van den Wijngaard

doi:10.1038/s41598-019-49096-y

Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms

Sara Botschuijver, Sophie A. van Diest, Isabelle A. M. van Thiel, Rafael S. Saia, Anne S. Strik, Zhumei Yu, Daniele Maria-Ferreira, Olaf Welting, Daniel Keszthelyi, Gary Jennings, Sigrid E. M. Heinsbroek, Ronald P. Oude Elferink, Frank H. J. Schuren, Wouter J. de Jonge, Rene M. van den Wijngaard^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	12530
Number of pages	11
Journal	Scientific Reports
Volume	9
DOIs	https://doi.org/10.1038/s41598-019-49096-y
Publication status	Published - 29 Aug 2019

Keywords

TRIGEMINAL SENSORY NEURONS
IN-VITRO
LIPID RAFTS
MAST-CELLS
TRPV1
ACTIVATION
SENSITIVITY
DISRUPTION
SYMPTOMS
EFFICACY

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10.1038/s41598-019-49096-y

Cite this

Botschuijver, S., van Diest, S. A., van Thiel, I. A. M., Saia, R. S., Strik, A. S., Yu, Z., Maria-Ferreira, D., Welting, O., Keszthelyi, D., Jennings, G., Heinsbroek, S. E. M., Elferink, R. P. O., Schuren, F. H. J., de Jonge, W. J., & van den Wijngaard, R. M. (2019). Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms. Scientific Reports, 9, [12530]. https://doi.org/10.1038/s41598-019-49096-y

Botschuijver, Sara ; van Diest, Sophie A. ; van Thiel, Isabelle A. M. ; Saia, Rafael S. ; Strik, Anne S. ; Yu, Zhumei ; Maria-Ferreira, Daniele ; Welting, Olaf ; Keszthelyi, Daniel ; Jennings, Gary ; Heinsbroek, Sigrid E. M. ; Elferink, Ronald P. Oude ; Schuren, Frank H. J. ; de Jonge, Wouter J. ; van den Wijngaard, Rene M. / Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms. In: Scientific Reports. 2019 ; Vol. 9.

@article{e00fc06a78034bb496faaf1f4a5e9408,

title = "Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms",

keywords = "TRIGEMINAL SENSORY NEURONS, IN-VITRO, LIPID RAFTS, MAST-CELLS, TRPV1, ACTIVATION, SENSITIVITY, DISRUPTION, SYMPTOMS, EFFICACY",

author = "Sara Botschuijver and {van Diest}, {Sophie A.} and {van Thiel}, {Isabelle A. M.} and Saia, {Rafael S.} and Strik, {Anne S.} and Zhumei Yu and Daniele Maria-Ferreira and Olaf Welting and Daniel Keszthelyi and Gary Jennings and Heinsbroek, {Sigrid E. M.} and Elferink, {Ronald P. Oude} and Schuren, {Frank H. J.} and {de Jonge}, {Wouter J.} and {van den Wijngaard}, {Rene M.}",

year = "2019",

month = aug,

day = "29",

doi = "10.1038/s41598-019-49096-y",

language = "English",

volume = "9",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

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Botschuijver, S, van Diest, SA, van Thiel, IAM, Saia, RS, Strik, AS, Yu, Z, Maria-Ferreira, D, Welting, O, Keszthelyi, D, Jennings, G, Heinsbroek, SEM, Elferink, RPO, Schuren, FHJ, de Jonge, WJ & van den Wijngaard, RM 2019, 'Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms', Scientific Reports, vol. 9, 12530. https://doi.org/10.1038/s41598-019-49096-y

Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms. / Botschuijver, Sara; van Diest, Sophie A.; van Thiel, Isabelle A. M.; Saia, Rafael S.; Strik, Anne S.; Yu, Zhumei; Maria-Ferreira, Daniele; Welting, Olaf; Keszthelyi, Daniel; Jennings, Gary; Heinsbroek, Sigrid E. M.; Elferink, Ronald P. Oude; Schuren, Frank H. J.; de Jonge, Wouter J.; van den Wijngaard, Rene M.

In: Scientific Reports, Vol. 9, 12530, 29.08.2019.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms

AU - Botschuijver, Sara

AU - van Diest, Sophie A.

AU - van Thiel, Isabelle A. M.

AU - Saia, Rafael S.

AU - Strik, Anne S.

AU - Yu, Zhumei

AU - Maria-Ferreira, Daniele

AU - Welting, Olaf

AU - Keszthelyi, Daniel

AU - Jennings, Gary

AU - Heinsbroek, Sigrid E. M.

AU - Elferink, Ronald P. Oude

AU - Schuren, Frank H. J.

AU - de Jonge, Wouter J.

AU - van den Wijngaard, Rene M.

PY - 2019/8/29

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KW - TRIGEMINAL SENSORY NEURONS

KW - IN-VITRO

KW - LIPID RAFTS

KW - MAST-CELLS

KW - TRPV1

KW - ACTIVATION

KW - SENSITIVITY

KW - DISRUPTION

KW - SYMPTOMS

KW - EFFICACY

U2 - 10.1038/s41598-019-49096-y

DO - 10.1038/s41598-019-49096-y

M3 - Article

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 12530

ER -