Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms

Sara Botschuijver, Sophie A. van Diest, Isabelle A. M. van Thiel, Rafael S. Saia, Anne S. Strik, Zhumei Yu, Daniele Maria-Ferreira, Olaf Welting, Daniel Keszthelyi, Gary Jennings, Sigrid E. M. Heinsbroek, Ronald P. Oude Elferink, Frank H. J. Schuren, Wouter J. de Jonge, Rene M. van den Wijngaard*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number12530
Number of pages11
JournalScientific Reports
Volume9
DOIs
Publication statusPublished - 29 Aug 2019

Keywords

  • TRIGEMINAL SENSORY NEURONS
  • IN-VITRO
  • LIPID RAFTS
  • MAST-CELLS
  • TRPV1
  • ACTIVATION
  • SENSITIVITY
  • DISRUPTION
  • SYMPTOMS
  • EFFICACY

Cite this

Botschuijver, S., van Diest, S. A., van Thiel, I. A. M., Saia, R. S., Strik, A. S., Yu, Z., ... van den Wijngaard, R. M. (2019). Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms. Scientific Reports, 9, [12530]. https://doi.org/10.1038/s41598-019-49096-y
Botschuijver, Sara ; van Diest, Sophie A. ; van Thiel, Isabelle A. M. ; Saia, Rafael S. ; Strik, Anne S. ; Yu, Zhumei ; Maria-Ferreira, Daniele ; Welting, Olaf ; Keszthelyi, Daniel ; Jennings, Gary ; Heinsbroek, Sigrid E. M. ; Elferink, Ronald P. Oude ; Schuren, Frank H. J. ; de Jonge, Wouter J. ; van den Wijngaard, Rene M. / Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms. In: Scientific Reports. 2019 ; Vol. 9.
@article{e00fc06a78034bb496faaf1f4a5e9408,
title = "Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms",
keywords = "TRIGEMINAL SENSORY NEURONS, IN-VITRO, LIPID RAFTS, MAST-CELLS, TRPV1, ACTIVATION, SENSITIVITY, DISRUPTION, SYMPTOMS, EFFICACY",
author = "Sara Botschuijver and {van Diest}, {Sophie A.} and {van Thiel}, {Isabelle A. M.} and Saia, {Rafael S.} and Strik, {Anne S.} and Zhumei Yu and Daniele Maria-Ferreira and Olaf Welting and Daniel Keszthelyi and Gary Jennings and Heinsbroek, {Sigrid E. M.} and Elferink, {Ronald P. Oude} and Schuren, {Frank H. J.} and {de Jonge}, {Wouter J.} and {van den Wijngaard}, {Rene M.}",
year = "2019",
month = "8",
day = "29",
doi = "10.1038/s41598-019-49096-y",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

Botschuijver, S, van Diest, SA, van Thiel, IAM, Saia, RS, Strik, AS, Yu, Z, Maria-Ferreira, D, Welting, O, Keszthelyi, D, Jennings, G, Heinsbroek, SEM, Elferink, RPO, Schuren, FHJ, de Jonge, WJ & van den Wijngaard, RM 2019, 'Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms', Scientific Reports, vol. 9, 12530. https://doi.org/10.1038/s41598-019-49096-y

Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms. / Botschuijver, Sara; van Diest, Sophie A.; van Thiel, Isabelle A. M.; Saia, Rafael S.; Strik, Anne S.; Yu, Zhumei; Maria-Ferreira, Daniele; Welting, Olaf; Keszthelyi, Daniel; Jennings, Gary; Heinsbroek, Sigrid E. M.; Elferink, Ronald P. Oude; Schuren, Frank H. J.; de Jonge, Wouter J.; van den Wijngaard, Rene M.

In: Scientific Reports, Vol. 9, 12530, 29.08.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms

AU - Botschuijver, Sara

AU - van Diest, Sophie A.

AU - van Thiel, Isabelle A. M.

AU - Saia, Rafael S.

AU - Strik, Anne S.

AU - Yu, Zhumei

AU - Maria-Ferreira, Daniele

AU - Welting, Olaf

AU - Keszthelyi, Daniel

AU - Jennings, Gary

AU - Heinsbroek, Sigrid E. M.

AU - Elferink, Ronald P. Oude

AU - Schuren, Frank H. J.

AU - de Jonge, Wouter J.

AU - van den Wijngaard, Rene M.

PY - 2019/8/29

Y1 - 2019/8/29

KW - TRIGEMINAL SENSORY NEURONS

KW - IN-VITRO

KW - LIPID RAFTS

KW - MAST-CELLS

KW - TRPV1

KW - ACTIVATION

KW - SENSITIVITY

KW - DISRUPTION

KW - SYMPTOMS

KW - EFFICACY

U2 - 10.1038/s41598-019-49096-y

DO - 10.1038/s41598-019-49096-y

M3 - Article

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 12530

ER -