Millennium Pathways for Tractography: 40 grand challenges to shape the future of tractography

Maxime Descoteaux; Kurt G Schilling; Dogu Baran Aydogan; Christian Beaulieu; Elena Borra; Maxime Chamberland; Alessandro Daducci; Alberto De Luca; Flavio Dell'Acqua; Jessica Dubois; Tim B Dyrby; Shawna Farquharson; Stephanie Forkel; Martijn Froeling; Alessandra Griffa; Mareike Grotheer; Pamela Guevara; Suzanne N Haber; Vinod Kumar Jangir; Alexander Leemans; Joël Lefebvre; Ching-Po Lin; Graham Little; Chun-Yi Zac Lo; Chiara Maffei; Helen S Mayberg; Jennifer A McNab; Pratik Mukherjee; Lauren J O'Donnell; Martin Parent; Carlo Pierpaoli; Francois Rheault; Kathleen S Rockland; Alard Roebroeck; Ariel Rokem; R Jarrett Rushmore; Silvio Sarubbo; Simona Schiavi; Stamatios N Sotiropoulos; Diego Szczupak; Michel Thiebaut de Schotten; J-Donald Tournier; Francesco Vergani; Joseph Yuan-Mou Yang; Fan Zhang; Derek Jones; Laurent Petit

Millennium Pathways for Tractography: 40 grand challenges to shape the future of tractography

Maxime Descoteaux
, Kurt G Schilling
, Dogu Baran Aydogan
, Christian Beaulieu
, Elena Borra
, Maxime Chamberland
, Alessandro Daducci
, Alberto De Luca
, Flavio Dell'Acqua
, Jessica Dubois
, Tim B Dyrby
, Shawna Farquharson
, Stephanie Forkel
, Martijn Froeling
, Alessandra Griffa
, Mareike Grotheer
, Pamela Guevara
, Suzanne N Haber
, Vinod Kumar Jangir
, Alexander Leemans

Joël Lefebvre, Ching-Po Lin, Graham Little, Chun-Yi Zac Lo, Chiara Maffei, Helen S Mayberg, Jennifer A McNab, Pratik Mukherjee, Lauren J O'Donnell, Martin Parent, Carlo Pierpaoli, Francois Rheault, Kathleen S Rockland, Alard Roebroeck, Ariel Rokem, R Jarrett Rushmore, Silvio Sarubbo, Simona Schiavi, Stamatios N Sotiropoulos, Diego Szczupak, Michel Thiebaut de Schotten, J-Donald Tournier, Francesco Vergani, Joseph Yuan-Mou Yang, Fan Zhang, Derek Jones, Laurent Petit

Multiscale Imaging of Brain Connectivity

Research output: Working paper / Preprint › Preprint

Abstract

In the spirit of the historic that heralded a new era for mathematics, the newly formed International Society for Tractography (IST) has launched the , a community-driven roadmap designed to shape the future of the field. Conceived during the inaugural , this initiative reflects a collective vision for advancing tractography over the coming decade and beyond. The roadmap consists of 40 grand challenges, developed by international experts and organized into seven categories spanning three overarching themes: neuroanatomy, tractography methods, and clinical applications. By defining shared short-, medium-, and long-term goals, these pathways provide a structured framework to confront fundamental limitations, promote rigorous validation, and accelerate the translation of tractography into a robust tool for neuroscience and medicine. Ultimately, the aim to guide and inspire future research and collaboration, ensuring the continued scientific and clinical relevance of tractography well into the future.

Original language	English
Publisher	Cornell University - arXiv
Number of pages	45
Publication status	Published - 30 Sept 2025

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https://arxiv.org/abs/2509.26259Licence: CC BY

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Descoteaux, M., Schilling, K. G., Aydogan, D. B., Beaulieu, C., Borra, E., Chamberland, M., Daducci, A., Luca, A. D., Dell'Acqua, F., Dubois, J., Dyrby, T. B., Farquharson, S., Forkel, S., Froeling, M., Griffa, A., Grotheer, M., Guevara, P., Haber, S. N., Jangir, V. K., ... Petit, L. (2025). Millennium Pathways for Tractography: 40 grand challenges to shape the future of tractography. Cornell University - arXiv. https://arxiv.org/abs/2509.26259

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title = "Millennium Pathways for Tractography: 40 grand challenges to shape the future of tractography",

abstract = "In the spirit of the historic that heralded a new era for mathematics, the newly formed International Society for Tractography (IST) has launched the , a community-driven roadmap designed to shape the future of the field. Conceived during the inaugural , this initiative reflects a collective vision for advancing tractography over the coming decade and beyond. The roadmap consists of 40 grand challenges, developed by international experts and organized into seven categories spanning three overarching themes: neuroanatomy, tractography methods, and clinical applications. By defining shared short-, medium-, and long-term goals, these pathways provide a structured framework to confront fundamental limitations, promote rigorous validation, and accelerate the translation of tractography into a robust tool for neuroscience and medicine. Ultimately, the aim to guide and inspire future research and collaboration, ensuring the continued scientific and clinical relevance of tractography well into the future.",

author = "Maxime Descoteaux and Schilling, \{Kurt G\} and Aydogan, \{Dogu Baran\} and Christian Beaulieu and Elena Borra and Maxime Chamberland and Alessandro Daducci and Luca, \{Alberto De\} and Flavio Dell'Acqua and Jessica Dubois and Dyrby, \{Tim B\} and Shawna Farquharson and Stephanie Forkel and Martijn Froeling and Alessandra Griffa and Mareike Grotheer and Pamela Guevara and Haber, \{Suzanne N\} and Jangir, \{Vinod Kumar\} and Alexander Leemans and Jo{\"e}l Lefebvre and Ching-Po Lin and Graham Little and \{Zac Lo\}, Chun-Yi and Chiara Maffei and Mayberg, \{Helen S\} and McNab, \{Jennifer A\} and Pratik Mukherjee and O'Donnell, \{Lauren J\} and Martin Parent and Carlo Pierpaoli and Francois Rheault and Rockland, \{Kathleen S\} and Alard Roebroeck and Ariel Rokem and Rushmore, \{R Jarrett\} and Silvio Sarubbo and Simona Schiavi and Sotiropoulos, \{Stamatios N\} and Diego Szczupak and \{de Schotten\}, \{Michel Thiebaut\} and J-Donald Tournier and Francesco Vergani and \{Yuan-Mou Yang\}, Joseph and Fan Zhang and Derek Jones and Laurent Petit",

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publisher = "Cornell University - arXiv",

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Descoteaux, M, Schilling, KG, Aydogan, DB, Beaulieu, C, Borra, E, Chamberland, M, Daducci, A, Luca, AD, Dell'Acqua, F, Dubois, J, Dyrby, TB, Farquharson, S, Forkel, S, Froeling, M, Griffa, A, Grotheer, M, Guevara, P, Haber, SN, Jangir, VK, Leemans, A, Lefebvre, J, Lin, C-P, Little, G, Zac Lo, C-Y, Maffei, C, Mayberg, HS, McNab, JA, Mukherjee, P, O'Donnell, LJ, Parent, M, Pierpaoli, C, Rheault, F, Rockland, KS, Roebroeck, A, Rokem, A, Rushmore, RJ, Sarubbo, S, Schiavi, S, Sotiropoulos, SN, Szczupak, D, de Schotten, MT, Tournier, J-D, Vergani, F, Yuan-Mou Yang, J, Zhang, F, Jones, D & Petit, L 2025 'Millennium Pathways for Tractography: 40 grand challenges to shape the future of tractography' Cornell University - arXiv. <https://arxiv.org/abs/2509.26259>

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AU - Descoteaux, Maxime

AU - Schilling, Kurt G

AU - Aydogan, Dogu Baran

AU - Beaulieu, Christian

AU - Borra, Elena

AU - Chamberland, Maxime

AU - Daducci, Alessandro

AU - Luca, Alberto De

AU - Dell'Acqua, Flavio

AU - Dubois, Jessica

AU - Dyrby, Tim B

AU - Farquharson, Shawna

AU - Forkel, Stephanie

AU - Froeling, Martijn

AU - Griffa, Alessandra

AU - Grotheer, Mareike

AU - Guevara, Pamela

AU - Haber, Suzanne N

AU - Jangir, Vinod Kumar

AU - Leemans, Alexander

AU - Lefebvre, Joël

AU - Lin, Ching-Po

AU - Little, Graham

AU - Zac Lo, Chun-Yi

AU - Maffei, Chiara

AU - Mayberg, Helen S

AU - McNab, Jennifer A

AU - Mukherjee, Pratik

AU - O'Donnell, Lauren J

AU - Parent, Martin

AU - Pierpaoli, Carlo

AU - Rheault, Francois

AU - Rockland, Kathleen S

AU - Roebroeck, Alard

AU - Rokem, Ariel

AU - Rushmore, R Jarrett

AU - Sarubbo, Silvio

AU - Schiavi, Simona

AU - Sotiropoulos, Stamatios N

AU - Szczupak, Diego

AU - de Schotten, Michel Thiebaut

AU - Tournier, J-Donald

AU - Vergani, Francesco

AU - Yuan-Mou Yang, Joseph

AU - Zhang, Fan

AU - Jones, Derek

AU - Petit, Laurent

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N2 - In the spirit of the historic that heralded a new era for mathematics, the newly formed International Society for Tractography (IST) has launched the , a community-driven roadmap designed to shape the future of the field. Conceived during the inaugural , this initiative reflects a collective vision for advancing tractography over the coming decade and beyond. The roadmap consists of 40 grand challenges, developed by international experts and organized into seven categories spanning three overarching themes: neuroanatomy, tractography methods, and clinical applications. By defining shared short-, medium-, and long-term goals, these pathways provide a structured framework to confront fundamental limitations, promote rigorous validation, and accelerate the translation of tractography into a robust tool for neuroscience and medicine. Ultimately, the aim to guide and inspire future research and collaboration, ensuring the continued scientific and clinical relevance of tractography well into the future.

AB - In the spirit of the historic that heralded a new era for mathematics, the newly formed International Society for Tractography (IST) has launched the , a community-driven roadmap designed to shape the future of the field. Conceived during the inaugural , this initiative reflects a collective vision for advancing tractography over the coming decade and beyond. The roadmap consists of 40 grand challenges, developed by international experts and organized into seven categories spanning three overarching themes: neuroanatomy, tractography methods, and clinical applications. By defining shared short-, medium-, and long-term goals, these pathways provide a structured framework to confront fundamental limitations, promote rigorous validation, and accelerate the translation of tractography into a robust tool for neuroscience and medicine. Ultimately, the aim to guide and inspire future research and collaboration, ensuring the continued scientific and clinical relevance of tractography well into the future.

M3 - Preprint

BT - Millennium Pathways for Tractography

PB - Cornell University - arXiv

ER -

Millennium Pathways for Tractography: 40 grand challenges to shape the future of tractography

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