TY - JOUR
T1 - Midlife dementia risk scores in a multi-ethnic population in the Netherlands
T2 - the HELIUS study
AU - Lindhout, Josephine
AU - van der Endt, Anne Roos
AU - Hoevenaar-Blom, Marieke P.
AU - van Dalen, Jan Willem
AU - Deckers, Kay
AU - Geerlings, Mirjam
AU - Galenkamp, Henrike
AU - Richard, Edo
AU - van Charante, Eric P. Moll
PY - 2025/2/1
Y1 - 2025/2/1
N2 - Background Migrant populations in the Netherlands may face greater dementia risk factor burden than Dutch natives.Objectives To study whether midlife dementia risk scores differ by ethnicity.Methods We calculated three validated dementia risk scores in participants aged 40-70 years of Dutch (n = 2978), South-Asian Surinamese (n = 2084), African Surinamese (n = 3135), Ghanaian (n = 1699), Turkish (n = 2000), and Moroccan (n = 2025) background, from the HELIUS study (Amsterdam, the Netherlands): Cardiovascular Risk Factors, Aging and Incidence of Dementia (CAIDE), LIfestyle for BRAin Health (LIBRA), and Australian National University-Alzheimer's Disease Risk Index (ANU-ADRI). We cross-sectionally compared scores between ethnicities using linear regression.Results Ethnic minority groups had higher risk scores than those with a Dutch background (CAIDE: +0.66-1.35; LIBRA: +0.66-1.43; ANU-ADRI: +2.75-7.25). CAIDE estimated an absolute 20-year incident dementia risk of 2.6% for Dutch, 3.4% for South-Asian Surinamese, 3.6% for Turkish, 3.7% for Moroccan, 3.7% for African Surinamese and 4.5% for Ghanaian populations. Differences were greater when removing age from scores (CAIDE +0.89-2.22; ANU-ADRI +3.03-8.20), implying that this higher risk score is independent of age.Conclusion Migrant populations had higher dementia risk scores than Dutch natives. Validation of these scores in migrant populations is warranted. If replicated, ethnicity should be considered when estimating dementia risk and developing preventive strategies for high-risk populations.
AB - Background Migrant populations in the Netherlands may face greater dementia risk factor burden than Dutch natives.Objectives To study whether midlife dementia risk scores differ by ethnicity.Methods We calculated three validated dementia risk scores in participants aged 40-70 years of Dutch (n = 2978), South-Asian Surinamese (n = 2084), African Surinamese (n = 3135), Ghanaian (n = 1699), Turkish (n = 2000), and Moroccan (n = 2025) background, from the HELIUS study (Amsterdam, the Netherlands): Cardiovascular Risk Factors, Aging and Incidence of Dementia (CAIDE), LIfestyle for BRAin Health (LIBRA), and Australian National University-Alzheimer's Disease Risk Index (ANU-ADRI). We cross-sectionally compared scores between ethnicities using linear regression.Results Ethnic minority groups had higher risk scores than those with a Dutch background (CAIDE: +0.66-1.35; LIBRA: +0.66-1.43; ANU-ADRI: +2.75-7.25). CAIDE estimated an absolute 20-year incident dementia risk of 2.6% for Dutch, 3.4% for South-Asian Surinamese, 3.6% for Turkish, 3.7% for Moroccan, 3.7% for African Surinamese and 4.5% for Ghanaian populations. Differences were greater when removing age from scores (CAIDE +0.89-2.22; ANU-ADRI +3.03-8.20), implying that this higher risk score is independent of age.Conclusion Migrant populations had higher dementia risk scores than Dutch natives. Validation of these scores in migrant populations is warranted. If replicated, ethnicity should be considered when estimating dementia risk and developing preventive strategies for high-risk populations.
KW - dementia
KW - ethnicity
KW - HELIUS study
KW - prevention
KW - risk score
KW - CARDIOVASCULAR-DISEASE RISK
KW - ETHNIC-DIFFERENCES
KW - LIFE-STYLE
KW - PREVENTION
KW - PREDICTION
KW - PREVALENCE
KW - VALIDATION
KW - MIGRANTS
KW - TURKISH
KW - LIBRA
U2 - 10.1093/pubmed/fdae315
DO - 10.1093/pubmed/fdae315
M3 - Article
SN - 1741-3842
JO - Journal of Public Health
JF - Journal of Public Health
M1 - fdae315
ER -