TY - JOUR
T1 - Microvascular Phenotyping in the Maastricht Study
T2 - Design and Main Findings, 2010-2018
AU - Li, Wenjie
AU - Schram, Miranda T.
AU - Sörensen, Ben M.
AU - van Agtmaal, Marnix J. M.
AU - Berendschot, Tos T. J. M.
AU - Webers, Carroll A. B.
AU - Jansen, Jacobus F. A.
AU - Backes, Walter H.
AU - Gronenschild, Ed H. B. M.
AU - Schalkwijk, Casper G.
AU - Stehouwer, Coen D. A.
AU - Houben, Alfons J. H. M.
N1 - © The Author(s) 2020. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2020/9
Y1 - 2020/9
N2 - Microvascular dysfunction (MVD) is a common pathophysiological change that occurs in various diseases, such as type 2 diabetes mellitus (T2DM), heart failure, dementia, and depression. Recent technical advances have enabled noninvasive measurement and quantification of microvascular changes in humans. In this paper, we describe the protocols of the microvascular measurements applied in the Maastricht Study, an ongoing prospective, population-based cohort study of persons aged 40-75 years being carried out in the southern part of the Netherlands (baseline data assessment, November 2010-January 2020). The study includes a variety of noninvasive measurements in skin, retina, brain, and sublingual tissue, as well as plasma and urine biomarker assessments. Following this, we summarize our main findings involving these microvascular measurements through the end of 2018. Finally, we provide a brief perspective on future microvascular investigations within the framework of the Maastricht Study.
AB - Microvascular dysfunction (MVD) is a common pathophysiological change that occurs in various diseases, such as type 2 diabetes mellitus (T2DM), heart failure, dementia, and depression. Recent technical advances have enabled noninvasive measurement and quantification of microvascular changes in humans. In this paper, we describe the protocols of the microvascular measurements applied in the Maastricht Study, an ongoing prospective, population-based cohort study of persons aged 40-75 years being carried out in the southern part of the Netherlands (baseline data assessment, November 2010-January 2020). The study includes a variety of noninvasive measurements in skin, retina, brain, and sublingual tissue, as well as plasma and urine biomarker assessments. Following this, we summarize our main findings involving these microvascular measurements through the end of 2018. Finally, we provide a brief perspective on future microvascular investigations within the framework of the Maastricht Study.
KW - cardiovascular disease
KW - microvascular dysfunction
KW - pathophysiology
KW - population-based studies
KW - type 2 diabetes
KW - LOW-GRADE INFLAMMATION
KW - ENDOTHELIAL DYSFUNCTION
KW - INSULIN-RESISTANCE
KW - DIAMETER RESPONSE
KW - VESSEL DIAMETER
KW - BLOOD-PRESSURE
KW - DISEASE
KW - MICROCIRCULATION
KW - ASSOCIATION
KW - DEPRESSION
U2 - 10.1093/aje/kwaa023
DO - 10.1093/aje/kwaa023
M3 - Article
C2 - 32077474
SN - 0002-9262
VL - 189
SP - 873
EP - 884
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 9
ER -