Microvascular dysfunction in the course of metabolic syndrome induced by high-fat diet

Cristiane Aoqui, Stefan Chmielewski, Elias Scherer, Ruth Eissler, Daniel Sollinger, Irina Heid, Rickmer Braren, Christoph Schmaderer, Remco T. A. Megens, Christian Weber, Uwe Heemann, Matthias Tschoep, Marcus Baumann*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Web of Science)

Abstract

Background: Metabolic syndrome (MetS) is associated with increased risk of cardiovascular disease (CVD). One important feature underlying the pathophysiology of many types of CVD is microvascular dysfunction. Although components of MetS are themselves CVD risk factors, the risk is increased when the syndrome is considered as one entity. We aimed to characterize microvascular function and some of its influencing factors in the course of MetS development. Methods: Development of MetS in C57BL/6 mice on a high-fat diet (HFD, 51% of energy from fat) was studied. The initial phase of MetS (I-MetS) was defined as the first 2 weeks of HFD feeding, with the fully developed phase occurring after 8 weeks of HFD. We characterized these phases by assessing changes in adiposity, blood pressure, and microvascular function. All data are presented as mean +/- standard error (SEM). Differences between cumulative dose-response curves of myograph experiments were calculated using non-linear regression analysis. In other experiments, comparisons between two groups were made with Student's t-test. Comparisons between more than two groups were made using one-way ANOVA with Tukey post-hoc test. A probability value
Original languageEnglish
Article number31
JournalCardiovascular Diabetology
Volume13
DOIs
Publication statusPublished - 3 Feb 2014

Keywords

  • High-fat diet
  • Metabolic syndrome
  • Hypertension
  • Microvascular dysfunction
  • Vasoconstriction

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