Microvascular dysfunction: Determinants and treatment, with a focus on hyperglycemia

Alfons J.H.M. Houben; Coen D.A. Stehouwer

doi:10.1016/j.endmts.2020.100073

Microvascular dysfunction: Determinants and treatment, with a focus on hyperglycemia

Alfons J.H.M. Houben^*, Coen D.A. Stehouwer

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Individuals with prediabetes or type 2 diabetes have an increased risk of diseases that are partly or entirely of microvascular origin (e.g. (lacunar) stroke, depression, cognitive decline, retinopathy, heart failure, chronic kidney disease, and neuropathy). These diseases are expressions of advanced microvascular dysfunction (MVD). Yet, MVD may develop already early and contribute to impaired insulin-mediated glucose uptake and subsequent metabolic insulin resistance, characterized by hyperglycemia. However, apart from hyperglycemia being a consequence of MVD, hyperglycemia can also (further) impair microvascular function, constituting a vicious cycle. In this review we shall discuss important evidence showing that MVD may precede and predict (pre)diabetes and related co-morbidities, and discuss the important determinants of early MVD. In addition, we shall discuss hyperglycemia being both a cause and consequence of MVD. Finally, we shall focus on prevention and treatment strategies for MVD.

Original language	English
Article number	100073
Number of pages	9
Journal	Endocrine and Metabolic Science
Volume	2
DOIs	https://doi.org/10.1016/j.endmts.2020.100073
Publication status	Published - 31 Mar 2021

Keywords

Cardiometabolic diseases
Glucose metabolism
Hyperglycemia
Microcirculation

Access to Document

10.1016/j.endmts.2020.100073Licence: CC BY-NC-ND

Cite this

@article{22a7829e1c2b450b89c0234c75c6c306,

title = "Microvascular dysfunction: Determinants and treatment, with a focus on hyperglycemia",

abstract = "Individuals with prediabetes or type 2 diabetes have an increased risk of diseases that are partly or entirely of microvascular origin (e.g. (lacunar) stroke, depression, cognitive decline, retinopathy, heart failure, chronic kidney disease, and neuropathy). These diseases are expressions of advanced microvascular dysfunction (MVD). Yet, MVD may develop already early and contribute to impaired insulin-mediated glucose uptake and subsequent metabolic insulin resistance, characterized by hyperglycemia. However, apart from hyperglycemia being a consequence of MVD, hyperglycemia can also (further) impair microvascular function, constituting a vicious cycle. In this review we shall discuss important evidence showing that MVD may precede and predict (pre)diabetes and related co-morbidities, and discuss the important determinants of early MVD. In addition, we shall discuss hyperglycemia being both a cause and consequence of MVD. Finally, we shall focus on prevention and treatment strategies for MVD.",

keywords = "Cardiometabolic diseases, Glucose metabolism, Hyperglycemia, Microcirculation",

author = "Houben, {Alfons J.H.M.} and Stehouwer, {Coen D.A.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2021",

month = mar,

day = "31",

doi = "10.1016/j.endmts.2020.100073",

language = "English",

volume = "2",

journal = "Endocrine and Metabolic Science",

issn = "2666-3961",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Microvascular dysfunction

T2 - Determinants and treatment, with a focus on hyperglycemia

AU - Houben, Alfons J.H.M.

AU - Stehouwer, Coen D.A.

PY - 2021/3/31

Y1 - 2021/3/31

N2 - Individuals with prediabetes or type 2 diabetes have an increased risk of diseases that are partly or entirely of microvascular origin (e.g. (lacunar) stroke, depression, cognitive decline, retinopathy, heart failure, chronic kidney disease, and neuropathy). These diseases are expressions of advanced microvascular dysfunction (MVD). Yet, MVD may develop already early and contribute to impaired insulin-mediated glucose uptake and subsequent metabolic insulin resistance, characterized by hyperglycemia. However, apart from hyperglycemia being a consequence of MVD, hyperglycemia can also (further) impair microvascular function, constituting a vicious cycle. In this review we shall discuss important evidence showing that MVD may precede and predict (pre)diabetes and related co-morbidities, and discuss the important determinants of early MVD. In addition, we shall discuss hyperglycemia being both a cause and consequence of MVD. Finally, we shall focus on prevention and treatment strategies for MVD.

AB - Individuals with prediabetes or type 2 diabetes have an increased risk of diseases that are partly or entirely of microvascular origin (e.g. (lacunar) stroke, depression, cognitive decline, retinopathy, heart failure, chronic kidney disease, and neuropathy). These diseases are expressions of advanced microvascular dysfunction (MVD). Yet, MVD may develop already early and contribute to impaired insulin-mediated glucose uptake and subsequent metabolic insulin resistance, characterized by hyperglycemia. However, apart from hyperglycemia being a consequence of MVD, hyperglycemia can also (further) impair microvascular function, constituting a vicious cycle. In this review we shall discuss important evidence showing that MVD may precede and predict (pre)diabetes and related co-morbidities, and discuss the important determinants of early MVD. In addition, we shall discuss hyperglycemia being both a cause and consequence of MVD. Finally, we shall focus on prevention and treatment strategies for MVD.

KW - Cardiometabolic diseases

KW - Glucose metabolism

KW - Hyperglycemia

KW - Microcirculation

U2 - 10.1016/j.endmts.2020.100073

DO - 10.1016/j.endmts.2020.100073

M3 - Article

SN - 2666-3961

VL - 2

JO - Endocrine and Metabolic Science

JF - Endocrine and Metabolic Science

M1 - 100073

ER -

Microvascular dysfunction: Determinants and treatment, with a focus on hyperglycemia

Abstract

Keywords

Access to Document

Fingerprint

Cite this