Microvascular and blood-brain barrier dysfunction in Alzheimer’s disease: New insights from quantitative magnetic resonance imaging

Harm Jan van de Haar

doi:10.26481/dis.20161110hh

Microvascular and blood-brain barrier dysfunction in Alzheimer’s disease: New insights from quantitative magnetic resonance imaging

Harm Jan van de Haar

Research output: Thesis › Doctoral Thesis › Internal

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Abstract

Cerebral microvascular abnormalities play a key role in people with Alzheimer’s disease. The condition of these small blood vessels can be assessed by means of an MRI scan with contrast. It is shown that there is a minor but measurable contrast leakage from the blood circulation into the brain. The so-called blood-brain barrier should ensure that the contrast agent remains within the blood circulation. The leakage observed is a sign, therefore, that this barrier is damaged in Alzheimer’s disease – even in people who show no signs of vascular damage at first sight.

Original language	English
Awarding Institution	Maastricht University
Supervisors/Advisors	Backes, Walter, Supervisor Verhey, Frans, Supervisor Jansen, Jaap, Co-Supervisor van Osch, Matthias J P, Co-Supervisor, External person
Award date	10 Nov 2016
Place of Publication	Maastricht
Publisher	Maastricht University
DOIs	https://doi.org/10.26481/dis.20161110hh
Publication status	Published - 2016

Keywords

Alzheimer's disease
MRI scan
diagnosis
blood-brain barrier

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Cite this

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title = "Microvascular and blood-brain barrier dysfunction in Alzheimer{\textquoteright}s disease: New insights from quantitative magnetic resonance imaging",

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AB - Cerebral microvascular abnormalities play a key role in people with Alzheimer’s disease. The condition of these small blood vessels can be assessed by means of an MRI scan with contrast. It is shown that there is a minor but measurable contrast leakage from the blood circulation into the brain. The so-called blood-brain barrier should ensure that the contrast agent remains within the blood circulation. The leakage observed is a sign, therefore, that this barrier is damaged in Alzheimer’s disease – even in people who show no signs of vascular damage at first sight.

KW - Alzheimer's disease

KW - MRI scan

KW - diagnosis

KW - blood-brain barrier

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Microvascular and blood-brain barrier dysfunction in Alzheimer’s disease: New insights from quantitative magnetic resonance imaging

Abstract

Keywords

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