Microtubule plus-end tracking proteins in neuronal development

Dieudonnée van de Willige, Casper C Hoogenraad, Anna Akhmanova

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Regulation of the microtubule cytoskeleton is of pivotal importance for neuronal development and function. One such regulatory mechanism centers on microtubule plus-end tracking proteins (+TIPs): structurally and functionally diverse regulatory factors, which can form complex macromolecular assemblies at the growing microtubule plus-ends. +TIPs modulate important properties of microtubules including their dynamics and their ability to control cell polarity, membrane transport and signaling. Several neurodevelopmental and neurodegenerative diseases are associated with mutations in +TIPs or with misregulation of these proteins. In this review, we focus on the role and regulation of +TIPs in neuronal development and associated disorders.

Original languageEnglish
Pages (from-to)2053-77
Number of pages25
JournalCellular and Molecular Life Sciences
Volume73
Issue number10
DOIs
Publication statusPublished - May 2016
Externally publishedYes

Keywords

  • Alzheimer Disease/pathology
  • Animals
  • Axons/metabolism
  • Brain Diseases/pathology
  • Cell Membrane/metabolism
  • Cell Polarity
  • Cytoskeleton/metabolism
  • Dendrites/metabolism
  • Humans
  • Microtubule-Associated Proteins/metabolism
  • Microtubules/metabolism
  • Mutation
  • Neurites/metabolism
  • Neurogenesis/physiology
  • Neurons/metabolism
  • Protein Binding
  • Signal Transduction
  • Synapses/metabolism

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