Microtubule plus-end tracking proteins in neuronal development

Dieudonnée van de Willige; Casper C Hoogenraad; Anna Akhmanova

doi:10.1007/s00018-016-2168-3

Microtubule plus-end tracking proteins in neuronal development

Dieudonnée van de Willige, Casper C Hoogenraad^*, Anna Akhmanova^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Regulation of the microtubule cytoskeleton is of pivotal importance for neuronal development and function. One such regulatory mechanism centers on microtubule plus-end tracking proteins (+TIPs): structurally and functionally diverse regulatory factors, which can form complex macromolecular assemblies at the growing microtubule plus-ends. +TIPs modulate important properties of microtubules including their dynamics and their ability to control cell polarity, membrane transport and signaling. Several neurodevelopmental and neurodegenerative diseases are associated with mutations in +TIPs or with misregulation of these proteins. In this review, we focus on the role and regulation of +TIPs in neuronal development and associated disorders.

Original language	English
Pages (from-to)	2053-77
Number of pages	25
Journal	Cellular and Molecular Life Sciences
Volume	73
Issue number	10
DOIs	https://doi.org/10.1007/s00018-016-2168-3
Publication status	Published - May 2016
Externally published	Yes

Keywords

Alzheimer Disease/pathology
Animals
Axons/metabolism
Brain Diseases/pathology
Cell Membrane/metabolism
Cell Polarity
Cytoskeleton/metabolism
Dendrites/metabolism
Humans
Microtubule-Associated Proteins/metabolism
Microtubules/metabolism
Mutation
Neurites/metabolism
Neurogenesis/physiology
Neurons/metabolism
Protein Binding
Signal Transduction
Synapses/metabolism

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Cite this

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title = "Microtubule plus-end tracking proteins in neuronal development",

abstract = "Regulation of the microtubule cytoskeleton is of pivotal importance for neuronal development and function. One such regulatory mechanism centers on microtubule plus-end tracking proteins (+TIPs): structurally and functionally diverse regulatory factors, which can form complex macromolecular assemblies at the growing microtubule plus-ends. +TIPs modulate important properties of microtubules including their dynamics and their ability to control cell polarity, membrane transport and signaling. Several neurodevelopmental and neurodegenerative diseases are associated with mutations in +TIPs or with misregulation of these proteins. In this review, we focus on the role and regulation of +TIPs in neuronal development and associated disorders. ",

keywords = "Alzheimer Disease/pathology, Animals, Axons/metabolism, Brain Diseases/pathology, Cell Membrane/metabolism, Cell Polarity, Cytoskeleton/metabolism, Dendrites/metabolism, Humans, Microtubule-Associated Proteins/metabolism, Microtubules/metabolism, Mutation, Neurites/metabolism, Neurogenesis/physiology, Neurons/metabolism, Protein Binding, Signal Transduction, Synapses/metabolism",

author = "{van de Willige}, Dieudonn{\'e}e and Hoogenraad, {Casper C} and Anna Akhmanova",

year = "2016",

month = may,

doi = "10.1007/s00018-016-2168-3",

language = "English",

volume = "73",

pages = "2053--77",

journal = "Cellular and Molecular Life Sciences",

issn = "1420-682X",

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number = "10",

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TY - JOUR

T1 - Microtubule plus-end tracking proteins in neuronal development

AU - van de Willige, Dieudonnée

AU - Hoogenraad, Casper C

AU - Akhmanova, Anna

PY - 2016/5

Y1 - 2016/5

N2 - Regulation of the microtubule cytoskeleton is of pivotal importance for neuronal development and function. One such regulatory mechanism centers on microtubule plus-end tracking proteins (+TIPs): structurally and functionally diverse regulatory factors, which can form complex macromolecular assemblies at the growing microtubule plus-ends. +TIPs modulate important properties of microtubules including their dynamics and their ability to control cell polarity, membrane transport and signaling. Several neurodevelopmental and neurodegenerative diseases are associated with mutations in +TIPs or with misregulation of these proteins. In this review, we focus on the role and regulation of +TIPs in neuronal development and associated disorders.

AB - Regulation of the microtubule cytoskeleton is of pivotal importance for neuronal development and function. One such regulatory mechanism centers on microtubule plus-end tracking proteins (+TIPs): structurally and functionally diverse regulatory factors, which can form complex macromolecular assemblies at the growing microtubule plus-ends. +TIPs modulate important properties of microtubules including their dynamics and their ability to control cell polarity, membrane transport and signaling. Several neurodevelopmental and neurodegenerative diseases are associated with mutations in +TIPs or with misregulation of these proteins. In this review, we focus on the role and regulation of +TIPs in neuronal development and associated disorders.

KW - Alzheimer Disease/pathology

KW - Animals

KW - Axons/metabolism

KW - Brain Diseases/pathology

KW - Cell Membrane/metabolism

KW - Cell Polarity

KW - Cytoskeleton/metabolism

KW - Dendrites/metabolism

KW - Humans

KW - Microtubule-Associated Proteins/metabolism

KW - Microtubules/metabolism

KW - Mutation

KW - Neurites/metabolism

KW - Neurogenesis/physiology

KW - Neurons/metabolism

KW - Protein Binding

KW - Signal Transduction

KW - Synapses/metabolism

U2 - 10.1007/s00018-016-2168-3

DO - 10.1007/s00018-016-2168-3

M3 - (Systematic) Review article

C2 - 26969328

SN - 1420-682X

VL - 73

SP - 2053

EP - 2077

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

IS - 10

ER -

Microtubule plus-end tracking proteins in neuronal development

Abstract

Keywords

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