Microtiter plate-sized standalone chip holder for microenvironmental physiological control in gas-impermeable microfluidic devices

Bjorn Harink; Severine Le Gac; David Barata; Clemens van Blitterswijk; Pamela Habibovic

doi:10.1039/c4lc00190g

Microtiter plate-sized standalone chip holder for microenvironmental physiological control in gas-impermeable microfluidic devices

Bjorn Harink
, Severine Le Gac
, David Barata
, Clemens van Blitterswijk
, Pamela Habibovic^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

We present a microtiter plate-sized standalone chip holder for precise control of physiological conditions inside closed microfluidic cell culture systems, made from gas-impermeable materials. Specifically, we demonstrate the suitability of the holder to support cell growth in a glass chip, to allow time-lapse imaging of live cells and the creation of a hypoxic environment, all relevant for applications in regenerative medicine research.

Original language	English
Pages (from-to)	1816-1820
Number of pages	5
Journal	Lab on A Chip
Volume	14
Issue number	11
DOIs	https://doi.org/10.1039/c4lc00190g
Publication status	Published - 2014

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10.1039/c4lc00190g

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title = "Microtiter plate-sized standalone chip holder for microenvironmental physiological control in gas-impermeable microfluidic devices",

abstract = "We present a microtiter plate-sized standalone chip holder for precise control of physiological conditions inside closed microfluidic cell culture systems, made from gas-impermeable materials. Specifically, we demonstrate the suitability of the holder to support cell growth in a glass chip, to allow time-lapse imaging of live cells and the creation of a hypoxic environment, all relevant for applications in regenerative medicine research.",

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AU - Harink, Bjorn

AU - Le Gac, Severine

AU - Barata, David

AU - van Blitterswijk, Clemens

AU - Habibovic, Pamela

PY - 2014

Y1 - 2014

N2 - We present a microtiter plate-sized standalone chip holder for precise control of physiological conditions inside closed microfluidic cell culture systems, made from gas-impermeable materials. Specifically, we demonstrate the suitability of the holder to support cell growth in a glass chip, to allow time-lapse imaging of live cells and the creation of a hypoxic environment, all relevant for applications in regenerative medicine research.

AB - We present a microtiter plate-sized standalone chip holder for precise control of physiological conditions inside closed microfluidic cell culture systems, made from gas-impermeable materials. Specifically, we demonstrate the suitability of the holder to support cell growth in a glass chip, to allow time-lapse imaging of live cells and the creation of a hypoxic environment, all relevant for applications in regenerative medicine research.

U2 - 10.1039/c4lc00190g

DO - 10.1039/c4lc00190g

M3 - Article

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SN - 1473-0197

VL - 14

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EP - 1820

JO - Lab on A Chip

JF - Lab on A Chip

IS - 11

ER -

Microtiter plate-sized standalone chip holder for microenvironmental physiological control in gas-impermeable microfluidic devices

Abstract

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