MicroRNAs orchestra the cellular processes driving failure of the heart

Robin Henricus Karel Oliver Verjans

Research output: ThesisDoctoral ThesisInternal

582 Downloads (Pure)

Abstract

Heart failure is a global health problem. MicroRNAs are tiny molecules with the ability to influence the progression of different diseases. For this reason, we identified several specific microRNA's that play a role in the development of heart failure. We then manipulated the identified microRNAs in heart muscle cells and laboratory animals to slow the progression of heart failure. MiR-221/222 appears to play a fundamental role. Slowing this particular RNA results in stiffer heart muscles and reduced pump function in laboratory animals. In addition, heart patients with a low miR-221/222 expression have poorer heart function. Further research is necessary to determine whether increasing miR-221/222 in the heart protects against heart failure.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Heymans, Stephane, Supervisor
  • Schroen, Blanche, Advisor
  • van Bilsen, Marc, Advisor
Award date23 Feb 2018
Place of PublicationMaastricht
Publisher
Print ISBNs9789462957879
DOIs
Publication statusPublished - 2018

Keywords

  • heart failure
  • molecules
  • pump function
  • progression

Cite this