MicroRNAs in the tumor endothelium: Novel controls on the angioregulatory switchboard

Roy Heusschen, Matthijs van Gink, Arjan W. Griffioen, Victor L. Thijssen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Web of Science)

Abstract

Tumor angiogenesis facilitates tumor metastasis and allows malignant tissues to grow beyond a diffusion limited size. It is a complex process that requires endothelial cells to execute specific steps during different phases. miRNAs are small non-coding RNAs that act as molecular switches to redirect the expression profile of a cell. Evidence is emerging that miRNAs are important players in endothelial cell biology and tumor angiogenesis. In this review we summarize the available data of miRNA expression in the endothelium. In addition, we describe the current knowledge regarding the function of miRNAs in endothelial cell biology. Finally, we discuss the potential applications of miRNA based treatment strategies in angiostatic cancer therapy.
Original languageEnglish
Pages (from-to)87-96
JournalBiochimica et Biophysica Acta-reviews on Cancer
Volume1805
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Cancer
  • Angiogenesis
  • miRNA
  • Endothelial cell

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