MicroRNAs in the tumor endothelium: Novel controls on the angioregulatory switchboard

Roy Heusschen; Matthijs van Gink; Arjan W. Griffioen; Victor L. Thijssen

doi:10.1016/j.bbcan.2009.09.005

MicroRNAs in the tumor endothelium: Novel controls on the angioregulatory switchboard

Roy Heusschen, Matthijs van Gink, Arjan W. Griffioen, Victor L. Thijssen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Tumor angiogenesis facilitates tumor metastasis and allows malignant tissues to grow beyond a diffusion limited size. It is a complex process that requires endothelial cells to execute specific steps during different phases. miRNAs are small non-coding RNAs that act as molecular switches to redirect the expression profile of a cell. Evidence is emerging that miRNAs are important players in endothelial cell biology and tumor angiogenesis. In this review we summarize the available data of miRNA expression in the endothelium. In addition, we describe the current knowledge regarding the function of miRNAs in endothelial cell biology. Finally, we discuss the potential applications of miRNA based treatment strategies in angiostatic cancer therapy.

Original language	English
Pages (from-to)	87-96
Journal	Biochimica et Biophysica Acta-reviews on Cancer
Volume	1805
Issue number	1
DOIs	https://doi.org/10.1016/j.bbcan.2009.09.005
Publication status	Published - Jan 2010

Keywords

Cancer
Angiogenesis
miRNA
Endothelial cell

Access to Document

10.1016/j.bbcan.2009.09.005

Cite this

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title = "MicroRNAs in the tumor endothelium: Novel controls on the angioregulatory switchboard",

abstract = "Tumor angiogenesis facilitates tumor metastasis and allows malignant tissues to grow beyond a diffusion limited size. It is a complex process that requires endothelial cells to execute specific steps during different phases. miRNAs are small non-coding RNAs that act as molecular switches to redirect the expression profile of a cell. Evidence is emerging that miRNAs are important players in endothelial cell biology and tumor angiogenesis. In this review we summarize the available data of miRNA expression in the endothelium. In addition, we describe the current knowledge regarding the function of miRNAs in endothelial cell biology. Finally, we discuss the potential applications of miRNA based treatment strategies in angiostatic cancer therapy. ",

keywords = "Cancer, Angiogenesis, miRNA, Endothelial cell",

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KW - Cancer

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