MicroRNAs in the heart : micromanagers and sentinels of cardiac disease

M.F. Corsten

doi:10.26481/dis.20120914mc

MicroRNAs in the heart : micromanagers and sentinels of cardiac disease

M.F. Corsten

Research output: Thesis › Doctoral Thesis › Internal

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Abstract

MicroRNAs are small molecules that have a great influence on a wide scale of cell functions and diseases. This dissertation describes the role of microRNAs in heart diseases and the involvement of individual microRNAs in inflammation of the heart. Manipulation of such microRNAs leads to protection of or, on the contrary, a higher sensitivity of the heart to high blood pressure or viruses. Also the ‘leaking’ of microRNAs from heart muscle cells during acute heart diseases can be measured in the blood which contributes to a quick diagnosis. Combined, these studies imply that microRNAs can be used for future treatments and diagnostic tests for cardiovascular diseases.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Maastricht University
Supervisors/Advisors	Heymans, Stephane, Supervisor Schroen, Blanche, Co-Supervisor
Award date	14 Sept 2012
Place of Publication	Maastricht
Publisher	Maastricht University
Print ISBNs	9789461083340
DOIs	https://doi.org/10.26481/dis.20120914mc
Publication status	Published - 1 Jan 2012

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