MicroRNAs in the heart : micromanagers and sentinels of cardiac disease

M.F. Corsten

    Research output: ThesisDoctoral ThesisInternal

    30 Downloads (Pure)

    Abstract

    MicroRNAs are small molecules that have a great influence on a wide scale of cell functions and diseases. This dissertation describes the role of microRNAs in heart diseases and the involvement of individual microRNAs in inflammation of the heart. Manipulation of such microRNAs leads to protection of or, on the contrary, a higher sensitivity of the heart to high blood pressure or viruses. Also the ‘leaking’ of microRNAs from heart muscle cells during acute heart diseases can be measured in the blood which contributes to a quick diagnosis. Combined, these studies imply that microRNAs can be used for future treatments and diagnostic tests for cardiovascular diseases.

    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • Maastricht University
    Supervisors/Advisors
    • Heymans, Stephane, Supervisor
    • Schroen, Blanche, Advisor
    Award date14 Sep 2012
    Place of PublicationMaastricht
    Publisher
    Print ISBNs9789461083340
    Publication statusPublished - 1 Jan 2012

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