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MicroRNAs in fracture healing and its treatment

  • Rald Victor Maria Groven

Research output: Thesis › Doctoral Thesis › External prepared

380 Downloads (Pure)

Abstract

This thesis investigated the role and expression of microRNAs in fracture healing and its treatment. The first part of this thesis focused on the expression of microRNAs in the normal fracture healing cascade as well as in a novel surgical tool that can be used to create a material to fill large bone defects. The second part aimed to investigate the expression of microRNAs in the setting of multiple trauma, with a particular focus on different surgical treatment strategies. Finally, the third part studied the expression of microRNAs after multiple trauma in the systemic circulation and the effect of a novel immunomodulatory therapy on the expression of microRNAs at the fracture site and in the systemic circulation.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • van Griensven, Martijn, Supervisor
  • Poeze, Martijn, Supervisor
  • Blokhuis, Taco, Co-Supervisor
Award date19 Nov 2024
Place of PublicationMaastricht
Publisher
Print ISBNs9789493391574
DOIs
Publication statusPublished - 2024

Keywords

  • MicroRNAs
  • fracture healing
  • trauma surgery
  • multiple trauma

Access to Document

  • Full TextFinal published version, 12.5 MB
  • CoverFinal published version, 34.3 KB
  • SummaryFinal published version, 99.9 KB
  • PropositionsFinal published version, 61.2 KB
  • ImpactFinal published version, 192 KB

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