MicroRNAs as Biomarkers for Myocardial Infarction

Kanita Salic, Leon J. De Windt*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Web of Science)

Abstract

MicroRNAs (miRs) are short non-coding RNA molecules involved in post-transcriptional gene regulation by binding to the 3' untranslated region of a messenger RNA (mRNA), thereby inhibiting the translation or inducing mRNA destabilization. MiRs are generally considered to act as intracellular mediators essential for normal cardiac function, and their deregulated expression profiles have been associated with cardiovascular diseases. Recent studies have revealed the existence of freely circulating miRs in human peripheral blood, which are present in a stable nature. This has raised the possibility that miRs may be released in the circulation and can serve as novel diagnostic markers for acute or chronic human disorders, including myocardial infarction (MI). This review summarizes the recent findings of miRs that fulfill the criteria of candidate biomarkers for MI.
Original languageEnglish
Pages (from-to)193-200
JournalCurrent Atherosclerosis Reports
Volume14
Issue number3
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Circulating microRNAs
  • Biomarkers
  • Myocardial infarction
  • Cardiovascular diagnostics

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