MicroRNA Profiling in Cartilage Ageing

Panagiotis Balaskas, Katarzyna Goljanek-Whysall, Peter Clegg, Yongxiang Fang, Andy Cremers, Pieter Emans, Tim Welting, Mandy Peffers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Web of Science)

Abstract

Osteoarthritis (OA) is the most common age-related joint disorder in man. MicroRNAs (miRNA), a class of small noncoding RNAs, are potential therapeutic targets for regulating molecular mechanisms in both disease and ageing. Whilst there is an increasing amount of research on the roles of miRNAs in ageing, there has been scant research on age-related changes in miRNA in a cartilage. We undertook a microarray study on young and old human cartilages. Findings were validated in an independent cohort. Contrasts between these samples identified twenty differentially expressed miRNAs in a cartilage from old donors, derived from an OA environment which clustered based on OA severity. We identified a number of recognised and novel miRNAs changing in cartilage ageing and OA including miR-126: a potential new candidate with a role in OA pathogenesis. These analyses represent important candidates that have the potential as cartilage ageing and OA biomarkers and therapeutic targets.

Original languageEnglish
Article number2713725
Number of pages11
JournalInternational Journal of Genomics
Volume2017
DOIs
Publication statusPublished - 2017

Keywords

  • HUMAN ARTICULAR CHONDROCYTES
  • TRANSCRIPTOME ANALYSIS
  • EXPRESSION PROFILES
  • STEM-CELLS
  • OSTEOARTHRITIS
  • TARGETS
  • GENE
  • PATHOGENESIS
  • BIOGENESIS
  • MECHANISMS

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