MicroRNA-155 Amplifies Nitric Oxide/cGMP Signaling and Impairs Vascular Angiotensin II Reactivity in Septic Shock

Francisco Vasques-Novoa; Tiago L. Laundos; Rui J. Cerqueira; Catarina Quina-Rodrigues; Ricardo Soares-dos-Reis; Fabiana Baganha; Sara Ribeiro; Luis Mendonca; Francisco Goncalves; Carlos Reguenga; Wouter Verhesen; Fatima Carneiro; Jose Artur Paiva; Blanche Schroen; Paulo Castro-Chaves; Perpetua Pinto-do-O; Diana S. Nascimento; Stephane Heymans; Adelino F. Leite-Moreira; Roberto Roncon-Albuquerque

doi:10.1097/CCM.0000000000003296

MicroRNA-155 Amplifies Nitric Oxide/cGMP Signaling and Impairs Vascular Angiotensin II Reactivity in Septic Shock

Francisco Vasques-Novoa, Tiago L. Laundos, Rui J. Cerqueira, Catarina Quina-Rodrigues, Ricardo Soares-dos-Reis, Fabiana Baganha, Sara Ribeiro, Luis Mendonca, Francisco Goncalves, Carlos Reguenga, Wouter Verhesen, Fatima Carneiro, Jose Artur Paiva, Blanche Schroen, Paulo Castro-Chaves, Perpetua Pinto-do-O, Diana S. Nascimento, Stephane Heymans, Adelino F. Leite-Moreira, Roberto Roncon-Albuquerque

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	E945-E954
Number of pages	10
Journal	Critical Care Medicine
Volume	46
Issue number	9
DOIs	https://doi.org/10.1097/CCM.0000000000003296
Publication status	Published - 1 Sep 2018

Keywords

angiotensin II
cardiomyopathy
endothelium
nitric oxide
septic shock
vasoplegia
SEVERE SEPSIS
DEPENDENT VASORELAXATION
MYOCARDIAL DYSFUNCTION
SYNTHASE
HEART
INJURY
MICE
THROMBOSPONDIN-1
PERMEABILITY
RESISTANCE

Access to Document

10.1097/CCM.0000000000003296

Cite this

Vasques-Novoa, F., Laundos, T. L., Cerqueira, R. J., Quina-Rodrigues, C., Soares-dos-Reis, R., Baganha, F., Ribeiro, S., Mendonca, L., Goncalves, F., Reguenga, C., Verhesen, W., Carneiro, F., Paiva, J. A., Schroen, B., Castro-Chaves, P., Pinto-do-O, P., Nascimento, D. S., Heymans, S., Leite-Moreira, A. F., & Roncon-Albuquerque, R. (2018). MicroRNA-155 Amplifies Nitric Oxide/cGMP Signaling and Impairs Vascular Angiotensin II Reactivity in Septic Shock. Critical Care Medicine, 46(9), E945-E954. https://doi.org/10.1097/CCM.0000000000003296

Vasques-Novoa, Francisco ; Laundos, Tiago L. ; Cerqueira, Rui J. ; Quina-Rodrigues, Catarina ; Soares-dos-Reis, Ricardo ; Baganha, Fabiana ; Ribeiro, Sara ; Mendonca, Luis ; Goncalves, Francisco ; Reguenga, Carlos ; Verhesen, Wouter ; Carneiro, Fatima ; Paiva, Jose Artur ; Schroen, Blanche ; Castro-Chaves, Paulo ; Pinto-do-O, Perpetua ; Nascimento, Diana S. ; Heymans, Stephane ; Leite-Moreira, Adelino F. ; Roncon-Albuquerque, Roberto. / MicroRNA-155 Amplifies Nitric Oxide/cGMP Signaling and Impairs Vascular Angiotensin II Reactivity in Septic Shock. In: Critical Care Medicine. 2018 ; Vol. 46, No. 9. pp. E945-E954.

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title = "MicroRNA-155 Amplifies Nitric Oxide/cGMP Signaling and Impairs Vascular Angiotensin II Reactivity in Septic Shock",

keywords = "angiotensin II, cardiomyopathy, endothelium, nitric oxide, septic shock, vasoplegia, SEVERE SEPSIS, DEPENDENT VASORELAXATION, MYOCARDIAL DYSFUNCTION, SYNTHASE, HEART, INJURY, MICE, THROMBOSPONDIN-1, PERMEABILITY, RESISTANCE",

author = "Francisco Vasques-Novoa and Laundos, {Tiago L.} and Cerqueira, {Rui J.} and Catarina Quina-Rodrigues and Ricardo Soares-dos-Reis and Fabiana Baganha and Sara Ribeiro and Luis Mendonca and Francisco Goncalves and Carlos Reguenga and Wouter Verhesen and Fatima Carneiro and Paiva, {Jose Artur} and Blanche Schroen and Paulo Castro-Chaves and Perpetua Pinto-do-O and Nascimento, {Diana S.} and Stephane Heymans and Leite-Moreira, {Adelino F.} and Roberto Roncon-Albuquerque",

year = "2018",

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doi = "10.1097/CCM.0000000000003296",

language = "English",

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Vasques-Novoa, F, Laundos, TL, Cerqueira, RJ, Quina-Rodrigues, C, Soares-dos-Reis, R, Baganha, F, Ribeiro, S, Mendonca, L, Goncalves, F, Reguenga, C, Verhesen, W, Carneiro, F, Paiva, JA, Schroen, B, Castro-Chaves, P, Pinto-do-O, P, Nascimento, DS, Heymans, S, Leite-Moreira, AF & Roncon-Albuquerque, R 2018, 'MicroRNA-155 Amplifies Nitric Oxide/cGMP Signaling and Impairs Vascular Angiotensin II Reactivity in Septic Shock', Critical Care Medicine, vol. 46, no. 9, pp. E945-E954. https://doi.org/10.1097/CCM.0000000000003296

MicroRNA-155 Amplifies Nitric Oxide/cGMP Signaling and Impairs Vascular Angiotensin II Reactivity in Septic Shock. / Vasques-Novoa, Francisco; Laundos, Tiago L.; Cerqueira, Rui J.; Quina-Rodrigues, Catarina; Soares-dos-Reis, Ricardo; Baganha, Fabiana; Ribeiro, Sara; Mendonca, Luis; Goncalves, Francisco; Reguenga, Carlos; Verhesen, Wouter; Carneiro, Fatima; Paiva, Jose Artur; Schroen, Blanche; Castro-Chaves, Paulo; Pinto-do-O, Perpetua; Nascimento, Diana S.; Heymans, Stephane; Leite-Moreira, Adelino F.; Roncon-Albuquerque, Roberto.

In: Critical Care Medicine, Vol. 46, No. 9, 01.09.2018, p. E945-E954.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - MicroRNA-155 Amplifies Nitric Oxide/cGMP Signaling and Impairs Vascular Angiotensin II Reactivity in Septic Shock

AU - Vasques-Novoa, Francisco

AU - Laundos, Tiago L.

AU - Cerqueira, Rui J.

AU - Quina-Rodrigues, Catarina

AU - Soares-dos-Reis, Ricardo

AU - Baganha, Fabiana

AU - Ribeiro, Sara

AU - Mendonca, Luis

AU - Goncalves, Francisco

AU - Reguenga, Carlos

AU - Verhesen, Wouter

AU - Carneiro, Fatima

AU - Paiva, Jose Artur

AU - Schroen, Blanche

AU - Castro-Chaves, Paulo

AU - Pinto-do-O, Perpetua

AU - Nascimento, Diana S.

AU - Heymans, Stephane

AU - Leite-Moreira, Adelino F.

AU - Roncon-Albuquerque, Roberto

PY - 2018/9/1

Y1 - 2018/9/1

KW - angiotensin II

KW - cardiomyopathy

KW - endothelium

KW - nitric oxide

KW - septic shock

KW - vasoplegia

KW - SEVERE SEPSIS

KW - DEPENDENT VASORELAXATION

KW - MYOCARDIAL DYSFUNCTION

KW - SYNTHASE

KW - HEART

KW - INJURY

KW - MICE

KW - THROMBOSPONDIN-1

KW - PERMEABILITY

KW - RESISTANCE

U2 - 10.1097/CCM.0000000000003296

DO - 10.1097/CCM.0000000000003296

M3 - Article

VL - 46

SP - E945-E954

JO - Critical Care Medicine

JF - Critical Care Medicine

SN - 0090-3493

IS - 9

ER -