MicroRNA-155 Amplifies Nitric Oxide/cGMP Signaling and Impairs Vascular Angiotensin II Reactivity in Septic Shock

Francisco Vasques-Novoa, Tiago L. Laundos, Rui J. Cerqueira, Catarina Quina-Rodrigues, Ricardo Soares-dos-Reis, Fabiana Baganha, Sara Ribeiro, Luis Mendonca, Francisco Goncalves, Carlos Reguenga, Wouter Verhesen, Fatima Carneiro, Jose Artur Paiva, Blanche Schroen, Paulo Castro-Chaves, Perpetua Pinto-do-O, Diana S. Nascimento, Stephane Heymans, Adelino F. Leite-Moreira, Roberto Roncon-Albuquerque

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)E945-E954
Number of pages10
JournalCritical Care Medicine
Volume46
Issue number9
DOIs
Publication statusPublished - 1 Sep 2018

Keywords

  • angiotensin II
  • cardiomyopathy
  • endothelium
  • nitric oxide
  • septic shock
  • vasoplegia
  • SEVERE SEPSIS
  • DEPENDENT VASORELAXATION
  • MYOCARDIAL DYSFUNCTION
  • SYNTHASE
  • HEART
  • INJURY
  • MICE
  • THROMBOSPONDIN-1
  • PERMEABILITY
  • RESISTANCE

Cite this

Vasques-Novoa, F., Laundos, T. L., Cerqueira, R. J., Quina-Rodrigues, C., Soares-dos-Reis, R., Baganha, F., Ribeiro, S., Mendonca, L., Goncalves, F., Reguenga, C., Verhesen, W., Carneiro, F., Paiva, J. A., Schroen, B., Castro-Chaves, P., Pinto-do-O, P., Nascimento, D. S., Heymans, S., Leite-Moreira, A. F., & Roncon-Albuquerque, R. (2018). MicroRNA-155 Amplifies Nitric Oxide/cGMP Signaling and Impairs Vascular Angiotensin II Reactivity in Septic Shock. Critical Care Medicine, 46(9), E945-E954. https://doi.org/10.1097/CCM.0000000000003296