Abstract
miRNAs (microRNAs) have been shown to play a role in myocardial fibrosis. The present study was designed to analyse whether alterations in miRNA expression contribute to the progression of myocardial fibrosis in AS (aortic valve stenosis) patients through up-regulation of the pro-fibrotic factor TGF-beta(1) (transforming growth factor-beta type 1). Endomyocardial biopsies were obtained from 28 patients with severe AS, and from the necropsies of 10 control subjects. AS patients presented increased myocardial CVF (collagen volume fraction) and TGF-beta(1) compared with the controls, these parameters being correlated in all patients. Patients were divided into two groups by cluster analysis according to their CVF: SF (severe fibrosis; CVF >15%; n =15) and non-SF (CVF
Original language | English |
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Pages (from-to) | 497-506 |
Journal | Clinical Science |
Volume | 126 |
Issue number | 7-8 |
DOIs | |
Publication status | Published - Apr 2014 |
Keywords
- cardiac remodelling
- miR-122
- myocardial fibrosis
- pressure overload
- procollagen C-terminal proteinase enhancer-1 (PCPE-1)
- transforming growth factor-beta type 1 (TGF-beta(1))