microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-beta(1) up-regulation

Javier Beaumont; Begona Lopez; Nerea Hermida; Blanche Schroen; Gorka San Jose; Stephane Heymans; Felix Valencia; Juan Jose Gomez-Doblas; Eduardo De Teresa; Javier Diez; Arantxa Gonzalez

doi:10.1042/CS20130538

microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-beta(1) up-regulation

Javier Beaumont, Begona Lopez, Nerea Hermida, Blanche Schroen, Gorka San Jose, Stephane Heymans, Felix Valencia, Juan Jose Gomez-Doblas, Eduardo De Teresa, Javier Diez, Arantxa Gonzalez^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

miRNAs (microRNAs) have been shown to play a role in myocardial fibrosis. The present study was designed to analyse whether alterations in miRNA expression contribute to the progression of myocardial fibrosis in AS (aortic valve stenosis) patients through up-regulation of the pro-fibrotic factor TGF-beta(1) (transforming growth factor-beta type 1). Endomyocardial biopsies were obtained from 28 patients with severe AS, and from the necropsies of 10 control subjects. AS patients presented increased myocardial CVF (collagen volume fraction) and TGF-beta(1) compared with the controls, these parameters being correlated in all patients. Patients were divided into two groups by cluster analysis according to their CVF: SF (severe fibrosis; CVF >15%; n =15) and non-SF (CVF

Original language	English
Pages (from-to)	497-506
Journal	Clinical Science
Volume	126
Issue number	7-8
DOIs	https://doi.org/10.1042/CS20130538
Publication status	Published - Apr 2014

Keywords

cardiac remodelling
miR-122
myocardial fibrosis
pressure overload
procollagen C-terminal proteinase enhancer-1 (PCPE-1)
transforming growth factor-beta type 1 (TGF-beta(1))

Access to Document

10.1042/CS20130538

Cite this

@article{a4398e813e924a82a06e16f6b5253664,

title = "microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-beta(1) up-regulation",

abstract = "miRNAs (microRNAs) have been shown to play a role in myocardial fibrosis. The present study was designed to analyse whether alterations in miRNA expression contribute to the progression of myocardial fibrosis in AS (aortic valve stenosis) patients through up-regulation of the pro-fibrotic factor TGF-beta(1) (transforming growth factor-beta type 1). Endomyocardial biopsies were obtained from 28 patients with severe AS, and from the necropsies of 10 control subjects. AS patients presented increased myocardial CVF (collagen volume fraction) and TGF-beta(1) compared with the controls, these parameters being correlated in all patients. Patients were divided into two groups by cluster analysis according to their CVF: SF (severe fibrosis; CVF >15%; n =15) and non-SF (CVF ",

keywords = "cardiac remodelling, miR-122, myocardial fibrosis, pressure overload, procollagen C-terminal proteinase enhancer-1 (PCPE-1), transforming growth factor-beta type 1 (TGF-beta(1))",

author = "Javier Beaumont and Begona Lopez and Nerea Hermida and Blanche Schroen and Jose, {Gorka San} and Stephane Heymans and Felix Valencia and {Jose Gomez-Doblas}, Juan and {De Teresa}, Eduardo and Javier Diez and Arantxa Gonzalez",

year = "2014",

month = apr,

doi = "10.1042/CS20130538",

language = "English",

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pages = "497--506",

journal = "Clinical Science",

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T1 - microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-beta(1) up-regulation

AU - Beaumont, Javier

AU - Lopez, Begona

AU - Hermida, Nerea

AU - Schroen, Blanche

AU - Jose, Gorka San

AU - Heymans, Stephane

AU - Valencia, Felix

AU - Jose Gomez-Doblas, Juan

AU - De Teresa, Eduardo

AU - Diez, Javier

AU - Gonzalez, Arantxa

PY - 2014/4

Y1 - 2014/4

N2 - miRNAs (microRNAs) have been shown to play a role in myocardial fibrosis. The present study was designed to analyse whether alterations in miRNA expression contribute to the progression of myocardial fibrosis in AS (aortic valve stenosis) patients through up-regulation of the pro-fibrotic factor TGF-beta(1) (transforming growth factor-beta type 1). Endomyocardial biopsies were obtained from 28 patients with severe AS, and from the necropsies of 10 control subjects. AS patients presented increased myocardial CVF (collagen volume fraction) and TGF-beta(1) compared with the controls, these parameters being correlated in all patients. Patients were divided into two groups by cluster analysis according to their CVF: SF (severe fibrosis; CVF >15%; n =15) and non-SF (CVF

AB - miRNAs (microRNAs) have been shown to play a role in myocardial fibrosis. The present study was designed to analyse whether alterations in miRNA expression contribute to the progression of myocardial fibrosis in AS (aortic valve stenosis) patients through up-regulation of the pro-fibrotic factor TGF-beta(1) (transforming growth factor-beta type 1). Endomyocardial biopsies were obtained from 28 patients with severe AS, and from the necropsies of 10 control subjects. AS patients presented increased myocardial CVF (collagen volume fraction) and TGF-beta(1) compared with the controls, these parameters being correlated in all patients. Patients were divided into two groups by cluster analysis according to their CVF: SF (severe fibrosis; CVF >15%; n =15) and non-SF (CVF

KW - cardiac remodelling

KW - miR-122

KW - myocardial fibrosis

KW - pressure overload

KW - procollagen C-terminal proteinase enhancer-1 (PCPE-1)

KW - transforming growth factor-beta type 1 (TGF-beta(1))

U2 - 10.1042/CS20130538

DO - 10.1042/CS20130538

M3 - Article

C2 - 24168656

SN - 0143-5221

VL - 126

SP - 497

EP - 506

JO - Clinical Science

JF - Clinical Science

IS - 7-8

ER -