microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-beta(1) up-regulation

Javier Beaumont, Begona Lopez, Nerea Hermida, Blanche Schroen, Gorka San Jose, Stephane Heymans, Felix Valencia, Juan Jose Gomez-Doblas, Eduardo De Teresa, Javier Diez, Arantxa Gonzalez

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Scopus)
Original languageEnglish
Pages (from-to)497-506
JournalClinical Science
Volume126
Issue number7-8
DOIs
Publication statusPublished - Apr 2014

Keywords

  • cardiac remodelling
  • miR-122
  • myocardial fibrosis
  • pressure overload
  • procollagen C-terminal proteinase enhancer-1 (PCPE-1)
  • transforming growth factor-beta type 1 (TGF-beta(1))

Cite this

Beaumont, J., Lopez, B., Hermida, N., Schroen, B., Jose, G. S., Heymans, S., Valencia, F., Jose Gomez-Doblas, J., De Teresa, E., Diez, J., & Gonzalez, A. (2014). microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-beta(1) up-regulation. Clinical Science, 126(7-8), 497-506. https://doi.org/10.1042/CS20130538