microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-beta(1) up-regulation

Javier Beaumont, Begona Lopez, Nerea Hermida, Blanche Schroen, Gorka San Jose, Stephane Heymans, Felix Valencia, Juan Jose Gomez-Doblas, Eduardo De Teresa, Javier Diez, Arantxa Gonzalez*

*Corresponding author for this work

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Abstract

miRNAs (microRNAs) have been shown to play a role in myocardial fibrosis. The present study was designed to analyse whether alterations in miRNA expression contribute to the progression of myocardial fibrosis in AS (aortic valve stenosis) patients through up-regulation of the pro-fibrotic factor TGF-beta(1) (transforming growth factor-beta type 1). Endomyocardial biopsies were obtained from 28 patients with severe AS, and from the necropsies of 10 control subjects. AS patients presented increased myocardial CVF (collagen volume fraction) and TGF-beta(1) compared with the controls, these parameters being correlated in all patients. Patients were divided into two groups by cluster analysis according to their CVF: SF (severe fibrosis; CVF >15%; n =15) and non-SF (CVF
Original languageEnglish
Pages (from-to)497-506
JournalClinical Science
Volume126
Issue number7-8
DOIs
Publication statusPublished - Apr 2014

Keywords

  • cardiac remodelling
  • miR-122
  • myocardial fibrosis
  • pressure overload
  • procollagen C-terminal proteinase enhancer-1 (PCPE-1)
  • transforming growth factor-beta type 1 (TGF-beta(1))

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