microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-beta(1) up-regulation

Javier Beaumont, Begona Lopez, Nerea Hermida, Blanche Schroen, Gorka San Jose, Stephane Heymans, Felix Valencia, Juan Jose Gomez-Doblas, Eduardo De Teresa, Javier Diez, Arantxa Gonzalez*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

69 Citations (Web of Science)
Original languageEnglish
Pages (from-to)497-506
JournalClinical Science
Issue number7-8
Publication statusPublished - Apr 2014


  • cardiac remodelling
  • miR-122
  • myocardial fibrosis
  • pressure overload
  • procollagen C-terminal proteinase enhancer-1 (PCPE-1)
  • transforming growth factor-beta type 1 (TGF-beta(1))

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