TY - JOUR
T1 - Microporous calcium phosphate ceramics driving osteogenesis through surface architecture
AU - Zhang, Jingwei
AU - Barbieri, Davide
AU - ten Hoopen, Hetty
AU - de Bruijn, Joost D.
AU - van Blitterswijk, Clemens A.
AU - Yuan, Huipin
PY - 2015/3
Y1 - 2015/3
N2 - The presence of micropores in calcium phosphate (CaP) ceramics has shown its important role in initiating inductive bone formation in ectopic sites. To investigate how microporous CaP ceramics trigger osteoinduction, we optimized two biphasic CaP ceramics (i.e., BCP-R and BCP-S) to have the same chemical composition, equivalent surface area per volume, comparable protein adsorption, similar ion (i.e., calcium and phosphate) exchange and the same surface mineralization potential, but different surface architecture. In particular, BCP-R had a surface roughness (Ra) of 325.4 ? 58.9 nm while for BCP-S it was 231.6 ? 35.7 nm. Ceramic blocks with crossing or noncrossing channels of 250, 500, 1000, and 2000 ?m were implanted in paraspinal muscle of dogs for 12 weeks. The percentage of bone volume in the channels was not affected by the type of pores (i.e., crossing vs. closed) or their size, but it was greatly influenced by the ceramic type (i.e., BCP-R vs. BCP-S). Significantly, more bone was formed in the channels of BCP-R than in those of BCP-S. Since the two CaP ceramics differed only in their surface architecture, the results hereby demonstrate that microporous CaP ceramics may induce ectopic osteogenesis through surface architecture.? 2014
AB - The presence of micropores in calcium phosphate (CaP) ceramics has shown its important role in initiating inductive bone formation in ectopic sites. To investigate how microporous CaP ceramics trigger osteoinduction, we optimized two biphasic CaP ceramics (i.e., BCP-R and BCP-S) to have the same chemical composition, equivalent surface area per volume, comparable protein adsorption, similar ion (i.e., calcium and phosphate) exchange and the same surface mineralization potential, but different surface architecture. In particular, BCP-R had a surface roughness (Ra) of 325.4 ? 58.9 nm while for BCP-S it was 231.6 ? 35.7 nm. Ceramic blocks with crossing or noncrossing channels of 250, 500, 1000, and 2000 ?m were implanted in paraspinal muscle of dogs for 12 weeks. The percentage of bone volume in the channels was not affected by the type of pores (i.e., crossing vs. closed) or their size, but it was greatly influenced by the ceramic type (i.e., BCP-R vs. BCP-S). Significantly, more bone was formed in the channels of BCP-R than in those of BCP-S. Since the two CaP ceramics differed only in their surface architecture, the results hereby demonstrate that microporous CaP ceramics may induce ectopic osteogenesis through surface architecture.? 2014
KW - bone grafting
KW - calcium phosphate ceramics
KW - microstructure
KW - surface architecture
KW - osteogenesis
U2 - 10.1002/jbm.a.35272
DO - 10.1002/jbm.a.35272
M3 - Article
C2 - 25044678
VL - 103
SP - 1188
EP - 1199
JO - Journal of Biomedical Materials Research Part A
JF - Journal of Biomedical Materials Research Part A
SN - 1549-3296
IS - 3
ER -