Micronutrient status assessment in humans: Current methods of analysis and future trends

Ulrich Holler*, Stephan J. L. Bakker, Andre Dusterloh, Balz Frei, Josef Koehrle, Tobias Konz, Georg Lietz, Adrian McCann, Alexander J. Michels, Anne M. Molloy, Hitoshi Murakami, Dietrich Rein, Wim H. M. Saris, Karlheinz Schmidt, Kazutaka Shimbo, Soeren Schumacher, Cees Vermeer, Jim Kaput, Peter Weber, Manfred EggersdorferSerge Rezzi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Citations (Web of Science)

Abstract

Micronutrients are essential to health at every life stage and their deficiencies are associated with increased incidence of various pathophysiological states and poor quality of life. Efficient methods are therefore needed to monitor micronutrient status of individuals and to improve evidenced-based recommendations for populations. This review (i) reports current approaches to assess the vitamin and mineral status in humans, (ii) summarizes current analytical advantages and shortcomings and (iii) provides practical information for both nutrition research and nutritional status diagnostics. Future analytical perspectives are discussed in relation to micronutrient profiling, analytical sensitivity, and miniaturized technologies. (C) 2018 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)110-122
Number of pages13
JournalTrac-Trends in Analytical Chemistry
Volume102
DOIs
Publication statusPublished - May 2018

Keywords

  • Analytical methodology
  • Fat-soluble vitamins
  • Human nutrition
  • Marker for micronutrient status
  • Micronutrient status assessment
  • Minerals
  • Trace elements
  • Water-soluble vitamins
  • PERFORMANCE LIQUID-CHROMATOGRAPHY
  • TANDEM MASS-SPECTROMETRY
  • STABLE-ISOTOPE DILUTION
  • VITAMIN-D METABOLITES
  • HUMAN PLASMA
  • LC-MS/MS
  • SELENIUM STATUS
  • WHOLE-BLOOD
  • MICROBIOLOGICAL ASSAYS
  • IODINE DEFICIENCY

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