TY - JOUR
T1 - Micronutrient status assessment in humans
T2 - Current methods of analysis and future trends
AU - Holler, Ulrich
AU - Bakker, Stephan J. L.
AU - Dusterloh, Andre
AU - Frei, Balz
AU - Koehrle, Josef
AU - Konz, Tobias
AU - Lietz, Georg
AU - McCann, Adrian
AU - Michels, Alexander J.
AU - Molloy, Anne M.
AU - Murakami, Hitoshi
AU - Rein, Dietrich
AU - Saris, Wim H. M.
AU - Schmidt, Karlheinz
AU - Shimbo, Kazutaka
AU - Schumacher, Soeren
AU - Vermeer, Cees
AU - Kaput, Jim
AU - Weber, Peter
AU - Eggersdorfer, Manfred
AU - Rezzi, Serge
PY - 2018/5
Y1 - 2018/5
N2 - Micronutrients are essential to health at every life stage and their deficiencies are associated with increased incidence of various pathophysiological states and poor quality of life. Efficient methods are therefore needed to monitor micronutrient status of individuals and to improve evidenced-based recommendations for populations. This review (i) reports current approaches to assess the vitamin and mineral status in humans, (ii) summarizes current analytical advantages and shortcomings and (iii) provides practical information for both nutrition research and nutritional status diagnostics. Future analytical perspectives are discussed in relation to micronutrient profiling, analytical sensitivity, and miniaturized technologies. (C) 2018 Elsevier B.V. All rights reserved.
AB - Micronutrients are essential to health at every life stage and their deficiencies are associated with increased incidence of various pathophysiological states and poor quality of life. Efficient methods are therefore needed to monitor micronutrient status of individuals and to improve evidenced-based recommendations for populations. This review (i) reports current approaches to assess the vitamin and mineral status in humans, (ii) summarizes current analytical advantages and shortcomings and (iii) provides practical information for both nutrition research and nutritional status diagnostics. Future analytical perspectives are discussed in relation to micronutrient profiling, analytical sensitivity, and miniaturized technologies. (C) 2018 Elsevier B.V. All rights reserved.
KW - Analytical methodology
KW - Fat-soluble vitamins
KW - Human nutrition
KW - Marker for micronutrient status
KW - Micronutrient status assessment
KW - Minerals
KW - Trace elements
KW - Water-soluble vitamins
KW - PERFORMANCE LIQUID-CHROMATOGRAPHY
KW - TANDEM MASS-SPECTROMETRY
KW - STABLE-ISOTOPE DILUTION
KW - VITAMIN-D METABOLITES
KW - HUMAN PLASMA
KW - LC-MS/MS
KW - SELENIUM STATUS
KW - WHOLE-BLOOD
KW - MICROBIOLOGICAL ASSAYS
KW - IODINE DEFICIENCY
U2 - 10.1016/j.trac.2018.02.001
DO - 10.1016/j.trac.2018.02.001
M3 - (Systematic) Review article
SN - 0165-9936
VL - 102
SP - 110
EP - 122
JO - Trac-Trends in Analytical Chemistry
JF - Trac-Trends in Analytical Chemistry
ER -