Microcirculatory assessment of vascular diseases

Antonella Marcoccia, Peter F. Klein-Weigel*, Michael E. Gschwandtner, Jean-Claude Wautrecht, Jiri Matuska, Ulrich Rother, Alfons J. H. M. Houben

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

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Abstract

The term "microcirculation" refers to the terminal vascular network of the body, which includes arterioles, capillaries, venules as well as initial lymphatic vessels. Additionally, it insinuates to their unique function in thermoregulatior, fluid balance, maintenance of cellular exchange, and metabolism. Disturbances of microvascular function were identified to precede macrovascular involvement in the presence of cardiovascular risk factors and is the hallmark of terminal disease stages like critical limb or acral ischemia. Nevertheless, despite its obvious significance in vascular medicine assessment of microvascular function became increasingly neglected in the clinical institutions during the last decades and seems to play a subordinary role in medical education. We therefore provide an overview over relevant and clinically practicable methods to assess microcirculation in vascular medicine with critical estimations of their pros and cons and their perspectives in the future.

Original languageEnglish
Pages (from-to)175-186
Number of pages12
JournalVasa-European Journal of Vascular Medicine
Volume49
Issue number3
DOIs
Publication statusPublished - Apr 2020

Keywords

  • Capillary microscopy
  • laser speckled contrast analyzer
  • O2C
  • tcpO2
  • indociarine green fluorescence angiography
  • SPECKLE CONTRAST ANALYSIS
  • INTRAOPERATIVE FLUORESCENCE ANGIOGRAPHY
  • MICRO-LIGHTGUIDE SPECTROPHOTOMETRY
  • INVIVO CAPILLARY MICROSCOPY
  • ARTERIAL OCCLUSIVE DISEASE
  • PERIPHERAL-BLOOD PERFUSION
  • ULCER RISK INDEX
  • SYSTEMIC-SCLEROSIS
  • INDOCYANINE GREEN
  • NAILFOLD CAPILLAROSCOPY

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