Microbially conjugated bile salts found in human bile activate the bile salt receptors TGR5 and FXR

Keyphrases

• Bile Salts 100%
• TGR5 100%
• Farnesoid X Receptor 100%
• Human Bile 100%
• Conjugated Bile Acids 100%
• Portal Blood 11%
• Bile 11%
• Tyrosine 5%
• Phenylalanine 5%
• Cytokine Release 5%
• Intestine 5%
• Receptor Signaling 5%
• Cholic Acid 5%
• Transcription Factor 5%
• Leucine 5%
• Macrophages 5%
• Liver 5%
• Pancreatic Surgery 5%
• Na + 5%
• Cell-based 5%
• Lipopolysaccharide-induced 5%
• Host Specificity 5%
• Cell-free 5%
• Cell Surface Receptor 5%
• Receptor Activation 5%
• Systemic Circulation 5%
• Human Circulation 5%
• Receptor Isoforms 5%
• Protein Activation 5%
• Exporters 5%
• Gut-liver Axis 5%
• Taurocholate 5%
• Enterohepatic Circulation 5%
• Activating Ligands 5%
• Microbial Origin 5%
• Amidate 5%
• Apical Sodium-dependent Bile Acid Transporter 5%
• Protein Transporters 5%
• Inter-organ 5%

INIS

• humans 100%
• receptors 100%
• salts 100%
• bile 100%
• g-proteins 100%
• liver 19%
• blood 9%
• origin 9%
• proteins 9%
• host 9%
• levels 4%
• patients 4%
• surgery 4%
• pancreas 4%
• phenylalanine 4%
• tyrosine 4%
• macrophages 4%
• cytokines 4%
• sodium 4%
• affinity 4%
• bile acids 4%
• substrates 4%
• surfaces 4%
• intestines 4%
• ligands 4%
• lipopolysaccharides 4%
• cholic acid 4%
• transcription factors 4%
• leucine 4%

Medicine and Dentistry

• Bile Salt 100%
• G Protein Coupled Receptor 100%
• Farnesoid X Receptor 100%
• Bile 100%
• Intestine 5%
• Macrophage 5%
• Phenylalanine 5%
• Leucine 5%
• Gut 5%
• Lipopolysaccharide 5%
• Taurocholic Acid 5%
• Sodium Ion 5%
• Enterohepatic Circulation 5%
• Transcription Factors 5%
• Systemic Circulation 5%
• Receptor 5%
• Protein 5%
• Cholic Acid 5%
• Bile Acid 5%
• Pancreatic Surgery 5%
• Conjugate 5%
• Cytokine Release 5%
• Cell Surface Receptor 5%
• Etomidate 5%