MEXPRESS update 2019

Alexander Koch*, Jana Jeschke, Wim Van Criekinge, Manon van Engeland, Tim De Meyer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The recent growth in the number of publicly available cancer omics databases has been accompanied by the development of various tools that allow researchers to visually explore these data. In 2015, we built MEXPRESS, an online tool for the integration and visualization of gene expression, DNA methylation and clinical data from The Cancer Genome Atlas (TCGA), a large collection of publicly available multi-omics cancer data. MEXPRESS addresses the need for an easy-to-use, interactive application that allows researchers to identify dysregulated genes and their clinical relevance in cancer. Furthermore, while other tools typically do not support integrated visualization of expression and DNA methylation data in combination with the precise genomic location of the methylation, MEXPRESS is unique in how it depicts these diverse data types together. Motivated by the large number of users MEXPRESS has managed to attract over the past 3 years and the recent migration of all TCGA data to a new data portal, we developed a new version of MEXPRESS (https://mexpress.be). It contains the latest TCGA data, additional types of omics and clinical data and extra functionality, allowing users to explore mechanisms of gene dysregulation beyond expression and DNA methylation.

Original languageEnglish
Pages (from-to)W561-W565
Number of pages5
JournalNucleic Acids Research
Volume47
Issue numberW1
DOIs
Publication statusPublished - 2 Jul 2019

Keywords

  • GENE
  • METHYLATION
  • CANCER

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