Methylphenidate produces selective enhancement of declarative memory consolidation in healthy volunteers

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)

Abstract

RATIONALE: Methylphenidate inhibits the reuptake of dopamine and noradrenaline and is used to treat children with attention deficit hyperactivity disorder (ADHD). Besides reducing behavioral symptoms, it improves their cognitive function. There are also observations of methylphenidate-induced cognition enhancement in healthy adults, although studies in this area are relatively sparse. We assessed the possible memory-enhancing properties of methylphenidate. OBJECTIVE: In the current study, the possible enhancing effects of three doses of methylphenidate on declarative and working memory, attention, response inhibition and planning were investigated in healthy volunteers. METHODS: In a double blind placebo-controlled crossover study, 19 healthy young male volunteers were tested after a single dose of placebo or 10, 20 or 40 mg of methylphenidate. Cognitive performance testing included a word learning test as a measure of declarative memory, a spatial working memory test, a set-shifting test, a stop signal test and a computerized version of the Tower of London planning test. RESULTS: Declarative memory consolidation was significantly improved relative to placebo after 20 and 40 mg of methylphenidate. Methylphenidate also improved set shifting and stopped signal task performance but did not affect spatial working memory or planning. CONCLUSIONS: To the best of our knowledge, this is the first study reporting enhanced declarative memory consolidation after methylphenidate in a dose-related fashion over a dose range that is presumed to reflect a wide range of dopamine reuptake inhibition.
Original languageEnglish
Pages (from-to)611-619
Number of pages9
JournalPsychopharmacology
Volume221
Issue number4
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Methylphenidate
  • Dopamine
  • Declarative memory consolidation
  • EVENT-RELATED POTENTIALS
  • SPATIAL WORKING-MEMORY
  • YOUNG-ADULTS
  • TRYPTOPHAN DEPLETION
  • OBJECT LOCATIONS
  • D-AMPHETAMINE
  • HUMAN BRAIN
  • HUMANS
  • PERFORMANCE
  • ATTENTION

Cite this

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title = "Methylphenidate produces selective enhancement of declarative memory consolidation in healthy volunteers",
abstract = "RATIONALE: Methylphenidate inhibits the reuptake of dopamine and noradrenaline and is used to treat children with attention deficit hyperactivity disorder (ADHD). Besides reducing behavioral symptoms, it improves their cognitive function. There are also observations of methylphenidate-induced cognition enhancement in healthy adults, although studies in this area are relatively sparse. We assessed the possible memory-enhancing properties of methylphenidate. OBJECTIVE: In the current study, the possible enhancing effects of three doses of methylphenidate on declarative and working memory, attention, response inhibition and planning were investigated in healthy volunteers. METHODS: In a double blind placebo-controlled crossover study, 19 healthy young male volunteers were tested after a single dose of placebo or 10, 20 or 40 mg of methylphenidate. Cognitive performance testing included a word learning test as a measure of declarative memory, a spatial working memory test, a set-shifting test, a stop signal test and a computerized version of the Tower of London planning test. RESULTS: Declarative memory consolidation was significantly improved relative to placebo after 20 and 40 mg of methylphenidate. Methylphenidate also improved set shifting and stopped signal task performance but did not affect spatial working memory or planning. CONCLUSIONS: To the best of our knowledge, this is the first study reporting enhanced declarative memory consolidation after methylphenidate in a dose-related fashion over a dose range that is presumed to reflect a wide range of dopamine reuptake inhibition.",
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author = "A.M.W. Linssen and E.F.P.M. Vuurman and A. Sambeth and W.J. Riedel",
year = "2012",
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Methylphenidate produces selective enhancement of declarative memory consolidation in healthy volunteers. / Linssen, A.M.W.; Vuurman, E.F.P.M.; Sambeth, A.; Riedel, W.J.

In: Psychopharmacology, Vol. 221, No. 4, 06.2012, p. 611-619.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Methylphenidate produces selective enhancement of declarative memory consolidation in healthy volunteers

AU - Linssen, A.M.W.

AU - Vuurman, E.F.P.M.

AU - Sambeth, A.

AU - Riedel, W.J.

PY - 2012/6

Y1 - 2012/6

N2 - RATIONALE: Methylphenidate inhibits the reuptake of dopamine and noradrenaline and is used to treat children with attention deficit hyperactivity disorder (ADHD). Besides reducing behavioral symptoms, it improves their cognitive function. There are also observations of methylphenidate-induced cognition enhancement in healthy adults, although studies in this area are relatively sparse. We assessed the possible memory-enhancing properties of methylphenidate. OBJECTIVE: In the current study, the possible enhancing effects of three doses of methylphenidate on declarative and working memory, attention, response inhibition and planning were investigated in healthy volunteers. METHODS: In a double blind placebo-controlled crossover study, 19 healthy young male volunteers were tested after a single dose of placebo or 10, 20 or 40 mg of methylphenidate. Cognitive performance testing included a word learning test as a measure of declarative memory, a spatial working memory test, a set-shifting test, a stop signal test and a computerized version of the Tower of London planning test. RESULTS: Declarative memory consolidation was significantly improved relative to placebo after 20 and 40 mg of methylphenidate. Methylphenidate also improved set shifting and stopped signal task performance but did not affect spatial working memory or planning. CONCLUSIONS: To the best of our knowledge, this is the first study reporting enhanced declarative memory consolidation after methylphenidate in a dose-related fashion over a dose range that is presumed to reflect a wide range of dopamine reuptake inhibition.

AB - RATIONALE: Methylphenidate inhibits the reuptake of dopamine and noradrenaline and is used to treat children with attention deficit hyperactivity disorder (ADHD). Besides reducing behavioral symptoms, it improves their cognitive function. There are also observations of methylphenidate-induced cognition enhancement in healthy adults, although studies in this area are relatively sparse. We assessed the possible memory-enhancing properties of methylphenidate. OBJECTIVE: In the current study, the possible enhancing effects of three doses of methylphenidate on declarative and working memory, attention, response inhibition and planning were investigated in healthy volunteers. METHODS: In a double blind placebo-controlled crossover study, 19 healthy young male volunteers were tested after a single dose of placebo or 10, 20 or 40 mg of methylphenidate. Cognitive performance testing included a word learning test as a measure of declarative memory, a spatial working memory test, a set-shifting test, a stop signal test and a computerized version of the Tower of London planning test. RESULTS: Declarative memory consolidation was significantly improved relative to placebo after 20 and 40 mg of methylphenidate. Methylphenidate also improved set shifting and stopped signal task performance but did not affect spatial working memory or planning. CONCLUSIONS: To the best of our knowledge, this is the first study reporting enhanced declarative memory consolidation after methylphenidate in a dose-related fashion over a dose range that is presumed to reflect a wide range of dopamine reuptake inhibition.

KW - Methylphenidate

KW - Dopamine

KW - Declarative memory consolidation

KW - EVENT-RELATED POTENTIALS

KW - SPATIAL WORKING-MEMORY

KW - YOUNG-ADULTS

KW - TRYPTOPHAN DEPLETION

KW - OBJECT LOCATIONS

KW - D-AMPHETAMINE

KW - HUMAN BRAIN

KW - HUMANS

KW - PERFORMANCE

KW - ATTENTION

U2 - 10.1007/s00213-011-2605-9

DO - 10.1007/s00213-011-2605-9

M3 - Article

VL - 221

SP - 611

EP - 619

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 4

ER -