Methylglyoxal, the glyoxalase pathway and advanced glycation endproducts in type 2 diabetes and cardiovascular disease

Research output: ThesisDoctoral ThesisInternal

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Abstract

People suffering from type 2 diabetes are more likely to develop arteriosclerosis and are at sharply increased risk of developing cardiovascular disease. A possible explanation is that in people suffering from diabetes a higher number of sugared proteins (advanced glycation endproducts) accumulate in vascular calcifications, a process with damaging effects. This dissertation describes the relation between higher blood levels of sugared proteins and a higher risk of developing cardiovascular disease in people suffering from type 2 diabetes. Higher levels of sugared proteins in vascular calcifications are linked to a higher degree of inflammation and tissue necrosis from arteriosclerosis. Inhibiting the formation of sugared proteins may prevent cardiovascular disease and measurements of sugared proteins may improve predictions of cardiovascular disease in people suffering from type 2 diabetes.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Schalkwijk, Casper, Supervisor
  • Stehouwer, Coen, Supervisor
  • Wouters, Kim, Supervisor
Award date20 May 2015
Place of PublicationMaastricht
Publisher
Print ISBNs9789462596405
Publication statusPublished - 2015

Keywords

  • type 2 diabetes
  • arteriosclerosis
  • sugared proteins
  • cardiovascular disease

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