Methylglyoxal-derived stress: An emerging biological factor involved in the onset and progression of cancer

Akeila Bellahcene*, Marie-Julie Nokin, Vincent Castronovo, Casper Schalkwijk

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

42 Citations (Web of Science)

Abstract

Cancer is a disease characterised by uncontrolled growth and proliferation of cells. Tumours primarily show a higher rate of glucose uptake for lactate production even in the presence of functional mitochondria. An important metabolic consequence is intracellular formation of glucose-derived carbonyl reactive species such as methylglyoxal (MG). It has become clear that MG is the most potent glycation agent in our body, leading to alterations of proteins and DNA, and cellular dysfunction. In recent years, emerging evidence indicates that MG plays a role in the development of cancer. This review will examine studies regarding the effects of MG on cancer onset and progression and discuss their controversies. Finally, the utilisation of inhibitors and MG scavengers will be addressed in the context of MG-mediated stress blockade for cancer therapy.
Original languageEnglish
Pages (from-to)64-74
Number of pages11
JournalSeminars in Cancer Biology
Volume49
DOIs
Publication statusPublished - 1 Apr 2018

Keywords

  • Warburg
  • Cancer
  • Methylglyoxal stress
  • Glyoxalase 1
  • Glycolysis
  • GLYCATION END-PRODUCTS
  • SMOOTH-MUSCLE-CELLS
  • HUMAN PROSTATE-CANCER
  • ALDO-KETO REDUCTASES
  • NF-KAPPA-B
  • POSSIBLE REGULATORY ROLE
  • GLYOXALASE I INHIBITION
  • VEIN ENDOTHELIAL-CELLS
  • BREAST-CANCER
  • DIABETIC COMPLICATIONS

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