METHYLGLYOXAL, A HIGHLY REACTIVE DICARBONYL COMPOUND, IN DIABETES, ITS VASCULAR COMPLICATIONS, AND OTHER AGE-RELATED DISEASES

C. G. Schalkwijk*, C. D. A. Stehouwer

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Original languageEnglish
Pages (from-to)407-461
Number of pages55
JournalPhysiological Reviews
Volume100
Issue number1
DOIs
Publication statusPublished - Jan 2020

Keywords

  • advanced glycation end products
  • ageing
  • glyoxalase
  • methylglyoxal
  • obesity
  • type 2 diabetes mellitus
  • GLYCATION END-PRODUCTS
  • GLYOXALASE-I OVEREXPRESSION
  • NITRIC-OXIDE SYNTHASE
  • COPY-NUMBER VARIATION
  • HUMAN SERUM-ALBUMIN
  • BROMOBENZYLGLUTATHIONE CYCLOPENTYL DIESTER
  • INDUCED MITOCHONDRIAL DYSFUNCTION
  • INCIDENT CARDIOVASCULAR-DISEASE
  • RENIN-ANGIOTENSIN-ALDOSTERONE
  • ENDOTHELIAL-CELL METABOLISM

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