Methods of diffusion-weighted and functional magnetic resonance imaging investigated in the human brain at ultra-high-field

Arne Seehaus

doi:10.26481/dis.20160928as

Methods of diffusion-weighted and functional magnetic resonance imaging investigated in the human brain at ultra-high-field

Arne Seehaus

Research output: Thesis › Doctoral Thesis › Internal

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Abstract

Magnetic resonance imaging (MRI) allows to obtain various types of brain images. A particular MRI method is diffusion tensor imaging (DTI), which can visualize nerve fiber pathways. The method is indirect, involving complicated mathematical models to infer this kind of information from the raw data. Therefore, it has to be investigated whether the results match the actual fiber architecture in practice. Parts of this PhD thesis are concerned with this problem: DTI results were compared to microscopical scans of brain tissue, where nerve fibers had been stained. Doing so, it was shown that DTI indeed works as theoretically supposed to.

Original language	English
Awarding Institution	Maastricht University
Supervisors/Advisors	Goebel, Rainer, Supervisor Roebroeck, Alard, Co-Supervisor Peters, Judith, Co-Supervisor
Award date	28 Sept 2016
Place of Publication	Maastricht
Publisher	Maastricht University
DOIs	https://doi.org/10.26481/dis.20160928as
Publication status	Published - 2016

Keywords

DTI
histological validation
fiber architecture

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10.26481/dis.20160928as

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Cite this

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abstract = "Magnetic resonance imaging (MRI) allows to obtain various types of brain images. A particular MRI method is diffusion tensor imaging (DTI), which can visualize nerve fiber pathways. The method is indirect, involving complicated mathematical models to infer this kind of information from the raw data. Therefore, it has to be investigated whether the results match the actual fiber architecture in practice. Parts of this PhD thesis are concerned with this problem: DTI results were compared to microscopical scans of brain tissue, where nerve fibers had been stained. Doing so, it was shown that DTI indeed works as theoretically supposed to.",

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AB - Magnetic resonance imaging (MRI) allows to obtain various types of brain images. A particular MRI method is diffusion tensor imaging (DTI), which can visualize nerve fiber pathways. The method is indirect, involving complicated mathematical models to infer this kind of information from the raw data. Therefore, it has to be investigated whether the results match the actual fiber architecture in practice. Parts of this PhD thesis are concerned with this problem: DTI results were compared to microscopical scans of brain tissue, where nerve fibers had been stained. Doing so, it was shown that DTI indeed works as theoretically supposed to.

KW - DTI

KW - histological validation

KW - fiber architecture

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M3 - Doctoral Thesis

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Methods of diffusion-weighted and functional magnetic resonance imaging investigated in the human brain at ultra-high-field

Abstract

Keywords

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