Method development studies for repeatedly measuring anxiolytic drug effects in healthy humans

F. Klumpers, J. van Gerven, E. Prinssen, I. Niklson, F. Roesch, W.J. Riedel, J. Kenemans, J. Baas

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11 Citations (Scopus)

Abstract

Human experimental models for anxiety may serve as translational tools for translating preclinical psychopharmacological investigations into human studies. For the evaluation of drugs of which pharmacokinetics and pharmacodynamics are unidentified, repeating measurements after drug administration is necessary for characterising the time course of drug effects. In experiment 1, a threat-of-shock paradigm and adaptations of the Trier mental arithmetic test and the Stroop colour naming test were repeated four times within a day to evaluate whether anxiety responses to this test battery remain stable after repeated testing. This procedure was repeated on 4 days in a second experiment to evaluate suitability of the paradigm for a crossover design with multiple sessions. Results indicate no reductions or changes in fear potentiated startle, the main outcome measure for the threat paradigm, over test sessions or days. Skin conductance responses and subjective ratings under threat-of-shock showed significant fluctuations but also no systematic decline over time. Finally, the threat paradigm and Stroop test resulted in small increases in reported state anxiety while mental arithmetic produced larger effects that diminished after the first test day. It is concluded that especially the startle paradigm could be a useful new instrument for screening new anxiolytic drugs.
Original languageEnglish
Pages (from-to)657-666
Number of pages10
JournalJournal of Psychopharmacology
Volume24
Issue number5
DOIs
Publication statusPublished - May 2010

Keywords

  • anxiety
  • experimental model
  • fear
  • skin conductance response
  • startle reflex
  • FEAR-POTENTIATED STARTLE
  • EMOTION-MODULATED STARTLE
  • SOCIAL ANXIETY DISORDER
  • COLOR-WORD TEST
  • ACOUSTIC STARTLE
  • D-CYCLOSERINE
  • PREPULSE INHIBITION
  • STATE-ANXIETY
  • BASE-LINE
  • REFLEX

Cite this

Klumpers, F., van Gerven, J., Prinssen, E., Niklson, I., Roesch, F., Riedel, W. J., Kenemans, J., & Baas, J. (2010). Method development studies for repeatedly measuring anxiolytic drug effects in healthy humans. Journal of Psychopharmacology, 24(5), 657-666. https://doi.org/10.1177/0269881109103115