Methadone effectively attenuates acute and long-term consequences of neonatal repetitive procedural pain in a rat model

N.J. van den Hoogen*, T.J. de Geus, J. Patijn, D. Tibboel, E.A. Joosten

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)

Abstract

Background Painful procedures in early life cause acute pain and can alter pain processing at a spinal level lasting into adulthood. Current methods of analgesia seem unable to prevent both acute and long-term hypersensitivity associated with neonatal pain. The current study aims to prevent acute and long-term hypersensitivity associated with neonatal procedural pain using methadone analgesia in rat pups. Methods Sprague-Dawley rat pups received either methadone (1 mg/kg) or saline prior to repetitive needle pricks into the left hind paw from the day of birth (postnatal day (P)0) to P7. Control littermates received a tactile stimulus. Mechanical sensitivity was assessed during the neonatal period (P0-P7), from weaning to adulthood (3-7 weeks) and following surgical re-injury of the same dermatome in adulthood. Results Methadone administration completely reversed acute hypersensitivity from P0 to P7. In addition, neonatal methadone analgesia prevented prolonged hypersensitivity after re-injury in adulthood, without affecting sensitivity from weaning to adulthood. Conclusions The current study shows that neonatal methadone analgesia can attenuate acute as well as long-term hypersensitivity associated with neonatal procedural pain in a rat model. ImpactMethadone treatment attenuates acute and long-term hypersensitivity associated with neonatal pain in a rat model. Clinical effectiveness studies are urgently warranted to assess acute and long-term analgesic effectivity of methadone.
Original languageEnglish
Pages (from-to)1681-1686
Number of pages6
JournalPediatric Research
Volume89
Issue number7
Early online date27 Jan 2021
DOIs
Publication statusPublished - May 2021

Keywords

  • 5-year follow-up
  • analgesia
  • aspartate nmda receptor
  • exposure
  • injury
  • intensive-care
  • morphine infusion
  • pharmacokinetics
  • plasticity
  • sensitivity
  • INJURY
  • SENSITIVITY
  • ASPARTATE NMDA RECEPTOR
  • INTENSIVE-CARE
  • MORPHINE INFUSION
  • PHARMACOKINETICS
  • 5-YEAR FOLLOW-UP
  • EXPOSURE
  • ANALGESIA
  • PLASTICITY

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