TY - JOUR
T1 - Metastatic Uveal Melanoma
T2 - Treatment Strategies and Survival-Results from the Dutch Melanoma Treatment Registry
AU - Jochems, Anouk
AU - van der Kooij, Monique K.
AU - Fiocco, Marta
AU - Schouwenburg, Maartje G.
AU - Aarts, Maureen J.
AU - van Akkooi, Alexander C.
AU - van den Berkmortel, Franchette W. P. J.
AU - Blank, Christian U.
AU - van den Eertwegh, Alfonsus J. M.
AU - Franken, Margreet G.
AU - de Groot, JanWillem B.
AU - Haanen, John B. A. G.
AU - Hospers, Geke A. P.
AU - Koornstra, Rutger H.
AU - Kruit, Wim H. J.
AU - Louwman, Marieke
AU - Piersma, Djura
AU - van Rijn, Rozemarijn S.
AU - Suijkerbuijk, Karijn P. M.
AU - ten Tije, Albert J.
AU - Vreugdenhil, Gerard
AU - Wouters, Michel W. J. M.
AU - van Zeijl, Michiel C. T.
AU - van der Hoeven, Koos J. M.
AU - Kapiteijn, Ellen
PY - 2019/6/26
Y1 - 2019/6/26
N2 - Uveal melanoma (UM) is the most common primary intraocular tumor in adults. Up to 50% of UM patients will develop metastases. We present data of 175 metastatic UM patients diagnosed in the Netherlands between July 2012 and March 2018. In our cohort, elevated lactate dehydrogenase level (LDH) is an important factor associated with poorer survival (Hazard Ratio (HR) 9.0, 95% Confidence Interval (CI) 5.63-14.35), and the presence of liver metastases is negatively associated with survival (HR 2.09, 95%CI 1.07-4.08). We used data from the nation-wide Dutch Melanoma Treatment Registry (DMTR) providing a complete overview of the location of metastases at time of stage IV disease. In 154 (88%) patients, the liver was affected, and only 3 patients were reported to have brain metastases. In 63 (36%) patients, mutation analysis was performed, showing a GNA11 mutation in 28.6% and a GNAQ mutation in 49.2% of the analyzed patients. In the absence of standard care of treatment options, metastatic UM patients are often directed to clinical trials. Patients participating in clinical trials are often subject to selection and usually do not represent the entire metastatic UM population. By using our nation-wide cohort, we are able to describe real-life treatment choices made in metastatic UM patients and 1-year survival rates in selected groups of patients.
AB - Uveal melanoma (UM) is the most common primary intraocular tumor in adults. Up to 50% of UM patients will develop metastases. We present data of 175 metastatic UM patients diagnosed in the Netherlands between July 2012 and March 2018. In our cohort, elevated lactate dehydrogenase level (LDH) is an important factor associated with poorer survival (Hazard Ratio (HR) 9.0, 95% Confidence Interval (CI) 5.63-14.35), and the presence of liver metastases is negatively associated with survival (HR 2.09, 95%CI 1.07-4.08). We used data from the nation-wide Dutch Melanoma Treatment Registry (DMTR) providing a complete overview of the location of metastases at time of stage IV disease. In 154 (88%) patients, the liver was affected, and only 3 patients were reported to have brain metastases. In 63 (36%) patients, mutation analysis was performed, showing a GNA11 mutation in 28.6% and a GNAQ mutation in 49.2% of the analyzed patients. In the absence of standard care of treatment options, metastatic UM patients are often directed to clinical trials. Patients participating in clinical trials are often subject to selection and usually do not represent the entire metastatic UM population. By using our nation-wide cohort, we are able to describe real-life treatment choices made in metastatic UM patients and 1-year survival rates in selected groups of patients.
KW - uveal melanoma
KW - metastatic uveal melanoma
KW - survival
KW - treatment strategy
KW - prognostic factor
KW - HEPATIC PERFUSION
KW - PHASE-II
KW - MUTATIONS
KW - IPILIMUMAB
KW - CHEMOTHERAPY
KW - PROGNOSIS
KW - OUTCOMES
KW - SF3B1
KW - GNA11
KW - CARE
U2 - 10.3390/cancers11071007
DO - 10.3390/cancers11071007
M3 - Article
C2 - 31323802
VL - 11
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 7
M1 - 1007
ER -