TY - JOUR
T1 - Metabolomics profiling of Type D personality traits
AU - Li-Gao, Ruifang
AU - Bot, Mariska
AU - Kurilshikov, Alexander
AU - Willemsen, Gonneke
AU - van Greevenbroek, Marleen M.J.
AU - Schram, Miranda M.T.
AU - Stehouwer, Coen D.A.
AU - Fu, Jingyuan
AU - Zhernakova, Alexandra
AU - Penninx, Brenda W.J.H.
AU - De Geus, Eco J.C.
AU - Boomsma, Dorret I.
AU - Kupper, Nina
AU - BBMRI-NL Metabolomics Consortium
N1 - Funding Information:
The study was supported by ZonMw (project no 849200001 ), the European Regional Development Fund via OP-Zuid , the Province of Limburg , the Dutch Ministry of Economic Affairs (grant 31O.041 ), Stichting De Weijerhorst (Maastricht, the Netherlands), the Pearl String Initiative Diabetes (Amsterdam, the Netherlands), CARIM , School for Cardiovascular Diseases (Maastricht, the Netherlands) , School CAPHRI , Care and Public Health Research Institute (Maastricht, the Netherlands), NUTRIM , School of Nutrition and Translational Research in Metabolism (Maastricht, the Netherlands) , Stichting Annadal (Maastricht, the Netherlands), Health Foundation Limburg (Maastricht, the Netherlands) and by unrestricted grants from Janssen-Cilag B.V . (Tilburg, the Netherlands), Novo Nordisk Farma B.V . (Alphen aan den Rijn, the Netherlands) and Sanofi-Aventis Netherlands B.V . (Gouda, the Netherlands).
Funding Information:
This work was performed within the framework of the BBMRI Metabolomics Consortium funded by BBMRI-NL, a research infrastructure financed by the Dutch government through Netherlands Organisation for Scientific Research (NWO) (Grant Nos. 184.021.007 and 184033111 ).
Funding Information:
The infrastructure for the NESDA study ( www.nesda.nl ) is funded through the Geestkracht program of the Netherlands Organisation for Health Research and Development (Grant No. 10-000-1002 ) and financial contributions by participating universities and mental health care organizations (VU University Medical Center, GGZ inGeest, Leiden University Medical Center, Leiden University, GGZ Rivierduinen, University Medical Center Groningen, University of Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Rob Giel Onderzoekscentrum).
Funding Information:
Funding was obtained from the NWO and MagW/ZonMW (Grant Nos. 904-61-090, 985-10-002 , 904-61-193,480-04-004 , l400-05-717 , Addiction-31160008, Middelgroot-911-09-032, Spinozapremie 56-464-14192), BBMRI-NL (Grant No. 184.021.007 ), European Community\u2019s Seventh Framework Programme (2007\u20132013) ENGAGE ( HEALTH-F4-2007-201413 ), European Science Council (ERC Advanced Grant No. 230374 ), Rutgers University Cell and DNA Repository (National Institute of Mental Health Grant No. U24 MH068457-06 ), Avera Institute, and National Institutes of Health (Grant Nos. R01D0042157-01A and MH081802 ,Grand Opportunity Grant No. 1RC2 MH089951 ). We gratefully acknowledge NWO Grant No. 480-15-001/674 : Netherlands Twin Register Repository: researching the interplay between genome and environment.
Funding Information:
LifeLines-DEEP (LLD) is a subcohort of the Lifelines cohort study, with additional measurements and sample collection funded by CardioVasculair Onderzoek Nederland (Grant No. 2018-27 [to JF and AZ]), ERC-Starting grant (Grant No. 715772 [to AZ]), ERC-Consolidator grant (agreement 101001678 [to JF]), and NWO (Vidi Grant No. 016.178.056 [to AZ] and VICI Grant No. VI.C.202.022 [to JF], the Gravitation grant Exposome-NL ( 024.004.017 [to AZ]). SG holds scholarships from the Graduate School of Medical Sciences, University of Groningen. JF is also supported by the Netherlands Organ-on-Chip Initiative , an NWO Gravitation project ( 024.003.001 ) funded by the Ministry of Education, Culture and Science of the government of The Netherlands .
Publisher Copyright:
© 2024 The Authors
PY - 2025/1/1
Y1 - 2025/1/1
N2 - Objective: Type D (Distressed) personality combines negative affectivity (NA) and social inhibition (SI) and is associated with an increased risk of cardiometabolic diseases. Here, we examined the association of Type D traits with 230 (predominantly) lipid metabolites and metabolite ratios. Methods: Four Dutch cohorts were included, comprising 10,834 individuals. Type D personality traits were measured by self-report questionnaires. A proton nuclear magnetic resonance (NMR) metabolomics platform provided 149 absolute measures (98 belonging to lipoprotein subclasses) and 81 derived ratios. For all, linear regression analyses were performed within each cohort, followed by random-effects meta-analyses. A per-measure FDR q-value<0.05 was set as a study-wise significant association. Results: SI was significantly associated with a lower omega-3 fatty acids to total fatty acids (FAw3.FA%) ratio, and a lower free cholesterol to total lipids ratio in very small VLDL (XS.VLDL.FC%). FAw3.FA% was also associated to NA (no study-wise significance though). NA showed a suggestive replication (p-value<.05) of the previous reported associations with depression for 5 out of 18 metabolites from the same metabolomics platform: triglycerides in HDL, serum total triglycerides, VLDL cholesterol, mean diameter for VLDL particles and VLDL triglycerides. Conclusions: In this large meta-analysis, SI was associated with omega-3 fatty acids to total fatty acids ratio, which is suggestive of lower omega-3 fatty acid intake. Only some metabolite biomarkers showed tentative links to Type D and NA. In sum, it seems that there are no major alterations in lipid metabolism associated with Type D traits.
AB - Objective: Type D (Distressed) personality combines negative affectivity (NA) and social inhibition (SI) and is associated with an increased risk of cardiometabolic diseases. Here, we examined the association of Type D traits with 230 (predominantly) lipid metabolites and metabolite ratios. Methods: Four Dutch cohorts were included, comprising 10,834 individuals. Type D personality traits were measured by self-report questionnaires. A proton nuclear magnetic resonance (NMR) metabolomics platform provided 149 absolute measures (98 belonging to lipoprotein subclasses) and 81 derived ratios. For all, linear regression analyses were performed within each cohort, followed by random-effects meta-analyses. A per-measure FDR q-value<0.05 was set as a study-wise significant association. Results: SI was significantly associated with a lower omega-3 fatty acids to total fatty acids (FAw3.FA%) ratio, and a lower free cholesterol to total lipids ratio in very small VLDL (XS.VLDL.FC%). FAw3.FA% was also associated to NA (no study-wise significance though). NA showed a suggestive replication (p-value<.05) of the previous reported associations with depression for 5 out of 18 metabolites from the same metabolomics platform: triglycerides in HDL, serum total triglycerides, VLDL cholesterol, mean diameter for VLDL particles and VLDL triglycerides. Conclusions: In this large meta-analysis, SI was associated with omega-3 fatty acids to total fatty acids ratio, which is suggestive of lower omega-3 fatty acid intake. Only some metabolite biomarkers showed tentative links to Type D and NA. In sum, it seems that there are no major alterations in lipid metabolism associated with Type D traits.
KW - Lipids
KW - Negative affectivity
KW - NMR-based metabolomics
KW - Social inhibition
KW - Type D personality
U2 - 10.1016/j.jpsychores.2024.111994
DO - 10.1016/j.jpsychores.2024.111994
M3 - Article
SN - 0022-3999
VL - 188
JO - Journal of Psychosomatic Research
JF - Journal of Psychosomatic Research
M1 - 111994
ER -