Abstract
Sepsis, with its often devastating consequences for patients and their families, remains a major public health concern that poses an increasing financial burden. Early resuscitation together with the elucidation of the biological pathways and pathophysiological mechanisms with the use of "-omics" technologies have started changing the clinical and research landscape in sepsis. Metabolomics (i. e., the study of the metabolome), an "-omics" technology further down in the "-omics" cascade between the genome and the phenome, could be particularly fruitful in sepsis research with the potential to alter the clinical practice. Apart from its benefit for the individual patient, metabolomics has an impact on public health that extends beyond its applications in medicine. In this review, we present recent developments in metabolomics research in sepsis, with a focus on pneumonia, and we discuss the impact of metabolomics on public health, with a focus on free/libre open source software. (c) 2018 S. Karger AG, Basel
Original language | English |
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Pages (from-to) | 274-285 |
Number of pages | 12 |
Journal | Public Health Genomics |
Volume | 20 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2017 |
JEL classifications
- i18 - "Health: Government Policy; Regulation; Public Health"
Keywords
- Commons arrangements
- Free/libre open source software
- Metabolomics
- Public health
- Sepsis
- clinical research
- human
- metabolomics
- pneumonia
- priority journal
- public health
- Review
- sepsis
- software
- COMMUNITY-ACQUIRED PNEUMONIA
- INTERNATIONAL CONSENSUS DEFINITIONS
- CROHNS-DISEASE
- SUSCEPTIBILITY LOCI
- STAPHYLOCOCCUS-AUREUS PNEUMONIA
- PRECISION MEDICINE
- CLINICAL-CRITERIA
- INTENSIVE-CARE-UNIT
- SEPTIC SHOCK SEPSIS-3
- GENOME-WIDE ASSOCIATION