@article{bdc44295ba25491b8bbf6628637227ea,
title = "Metabolomics in epidemiologic research: challenges and opportunities for early-career epidemiologists",
abstract = "BackgroundThe application of metabolomics to epidemiologic studies is increasing.Aim of ReviewHere, we describe the challenges and opportunities facing early-career epidemiologists aiming to apply metabolomics to their research.Key Scientific Concepts of ReviewMany challenges inherent to metabolomics may provide early-career epidemiologists with the opportunity to play a pivotal role in answering critical methodological questions and moving the field forward. Although generating large-scale high-quality metabolomics data can be challenging, data can be accessed through public databases, collaboration with senior researchers or participation within interest groups. Such efforts may also assist with obtaining funding, provide knowledge on training resources, and help early-career epidemiologists to publish in the field of metabolomics.",
keywords = "Metabolomics, Epidemiology, Early-career scientists, Challenges, Opportunities, PROSTATE-CANCER RISK, HEPATOCELLULAR-CARCINOMA, SERUM METABOLITES, PROFILES, HYPERTENSION, ASSOCIATION, BIOMARKERS, LUNG",
author = "{van Roekel}, {Eline H.} and Erikka Loftfield and Kelly, {Rachel S.} and Zeleznik, {Oana A.} and Zanetti, {Krista A.}",
note = "Funding Information: Funding E.H. van Roekel was financially supported by Wereld Kanker Onderzoek Fonds (WKOF), as part of the World Cancer Research Fund International grant programme (Grant No. 2016/1620) and the GROW School for Oncology and Developmental Biology. E. Loftfield was supported by the Intramural Research Program of the National Institutes of Health, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services. R.S. Kelly was supported by a Discovery Award from The US Department of Defense (Grant No. W81XWH-17-1-0533), and a grant from the US NIH (Grant No. 1R01HL123915-01). O.A. Zeleznik was supported by grants from the NIH (Grant Nos. CA087969, CA050385). K.A. Zanetti was supported by the Extramural Research Program of the National Institutes of Health, Division of Cancer Control and Funding Information: Financial support for generating metabolomics data in a population-based study is mostly available via funding mechanisms open to senior scientists. Announcements such as that from the Next Generation Research Initiative of the NIH signal a shift towards research funding opportunities for early-and mid-career investigators. Early-career scientists may also be eligible for pilot study funding grants, such as those from the World Cancer Research Fund (http://www.wcrf.org/int/research-we-fund/grant Funding Information: Gaining access to existing data is an efficient and cost-effective way to gain experience in the field. The simplest option is represented by online databases, such as MetaboLights (https://www.ebi.ac.uk/metabolights/; mainly supported by the European Molecular Biology Laboratory, UK Medical Research Council and Wellcome Trust), and the National Institute of Health (NIH)-supported Metabolomics Workbench (http://www.metabolomicsworkbench.org/). Another way to gain access to data is to collaborate with a senior metabolomics researcher. There are generally more hypotheses than scientists to test them, and senior investigators may be particularly willing to host early-career epidemiologists with unique expertise, such as epidemiologic study design or statistical data analysis. Publisher Copyright: {\textcopyright} 2019, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2019",
month = jan,
doi = "10.1007/s11306-018-1468-z",
language = "English",
volume = "15",
journal = "Metabolomics",
issn = "1573-3882",
publisher = "Springer",
number = "1",
}