Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

Jolanda van der Velden*, Carlo G. Tocchetti, Gilda Varricchi, Anna Bianco, Vasco Sequeira, Denise Hilfiker-Kleiner, Nazha Hamdani, Adelino F. Leite-Moreira, Manuel Mayr, Ines Falcao-Pires, Thomas Thum, Dana K. Dawson, Jean-Luc Balligand, Stephane Heymans

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Web of Science)

Abstract

Disturbed metabolism as a consequence of obesity and diabetes may cause cardiac diseases (recently highlighted in the cardiovascular research spotlight issue on metabolic cardiomyopathies). 1 In turn, the metabolism of the heart may also be disturbed in genetic and acquired forms of hypertrophic cardiac disease. Herein, we provide an overview of recent insights on metabolic changes in genetic hypertrophic cardiomyopathy and discuss several therapies, which may be explored to target disturbed metabolism and prevent onset of cardiac hypertrophy.
Original languageEnglish
Pages (from-to)1273-1280
Number of pages8
JournalCardiovascular Research
Volume114
Issue number10
DOIs
Publication statusPublished - 1 Aug 2018

Keywords

  • Hypertrophic cardiomyopathy
  • Mutations
  • Metabolism
  • CARDIAC TROPONIN-T
  • SPONTANEOUSLY HYPERTENSIVE-RAT
  • LEFT-VENTRICULAR HYPERTROPHY
  • SARCOMERIC GENE-MUTATIONS
  • HEART-FAILURE
  • NITRIC-OXIDE
  • PERIPARTUM CARDIOMYOPATHY
  • MICROVASCULAR DYSFUNCTION
  • DIASTOLIC DYSFUNCTION
  • ATRIAL-FIBRILLATION

Cite this