Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

Jolanda van der Velden; Carlo G. Tocchetti; Gilda Varricchi; Anna Bianco; Vasco Sequeira; Denise Hilfiker-Kleiner; Nazha Hamdani; Adelino F. Leite-Moreira; Manuel Mayr; Ines Falcao-Pires; Thomas Thum; Dana K. Dawson; Jean-Luc Balligand; Stephane Heymans

doi:10.1093/cvr/cvy147

Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

Jolanda van der Velden^*, Carlo G. Tocchetti, Gilda Varricchi, Anna Bianco, Vasco Sequeira, Denise Hilfiker-Kleiner, Nazha Hamdani, Adelino F. Leite-Moreira, Manuel Mayr, Ines Falcao-Pires, Thomas Thum, Dana K. Dawson, Jean-Luc Balligand, Stephane Heymans

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Disturbed metabolism as a consequence of obesity and diabetes may cause cardiac diseases (recently highlighted in the cardiovascular research spotlight issue on metabolic cardiomyopathies). 1 In turn, the metabolism of the heart may also be disturbed in genetic and acquired forms of hypertrophic cardiac disease. Herein, we provide an overview of recent insights on metabolic changes in genetic hypertrophic cardiomyopathy and discuss several therapies, which may be explored to target disturbed metabolism and prevent onset of cardiac hypertrophy.

Original language	English
Pages (from-to)	1273-1280
Number of pages	8
Journal	Cardiovascular Research
Volume	114
Issue number	10
DOIs	https://doi.org/10.1093/cvr/cvy147
Publication status	Published - 1 Aug 2018

Keywords

Hypertrophic cardiomyopathy
Mutations
Metabolism
CARDIAC TROPONIN-T
SPONTANEOUSLY HYPERTENSIVE-RAT
LEFT-VENTRICULAR HYPERTROPHY
SARCOMERIC GENE-MUTATIONS
HEART-FAILURE
NITRIC-OXIDE
PERIPARTUM CARDIOMYOPATHY
MICROVASCULAR DYSFUNCTION
DIASTOLIC DYSFUNCTION
ATRIAL-FIBRILLATION

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van der Velden, J., Tocchetti, C. G., Varricchi, G., Bianco, A., Sequeira, V., Hilfiker-Kleiner, D., Hamdani, N., Leite-Moreira, A. F., Mayr, M., Falcao-Pires, I., Thum, T., Dawson, D. K., Balligand, J.-L., & Heymans, S. (2018). Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. Cardiovascular Research, 114(10), 1273-1280. https://doi.org/10.1093/cvr/cvy147

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title = "Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology",

abstract = "Disturbed metabolism as a consequence of obesity and diabetes may cause cardiac diseases (recently highlighted in the cardiovascular research spotlight issue on metabolic cardiomyopathies). 1 In turn, the metabolism of the heart may also be disturbed in genetic and acquired forms of hypertrophic cardiac disease. Herein, we provide an overview of recent insights on metabolic changes in genetic hypertrophic cardiomyopathy and discuss several therapies, which may be explored to target disturbed metabolism and prevent onset of cardiac hypertrophy.",

keywords = "Hypertrophic cardiomyopathy, Mutations, Metabolism, CARDIAC TROPONIN-T, SPONTANEOUSLY HYPERTENSIVE-RAT, LEFT-VENTRICULAR HYPERTROPHY, SARCOMERIC GENE-MUTATIONS, HEART-FAILURE, NITRIC-OXIDE, PERIPARTUM CARDIOMYOPATHY, MICROVASCULAR DYSFUNCTION, DIASTOLIC DYSFUNCTION, ATRIAL-FIBRILLATION",

author = "{van der Velden}, Jolanda and Tocchetti, {Carlo G.} and Gilda Varricchi and Anna Bianco and Vasco Sequeira and Denise Hilfiker-Kleiner and Nazha Hamdani and Leite-Moreira, {Adelino F.} and Manuel Mayr and Ines Falcao-Pires and Thomas Thum and Dawson, {Dana K.} and Jean-Luc Balligand and Stephane Heymans",

year = "2018",

month = aug,

day = "1",

doi = "10.1093/cvr/cvy147",

language = "English",

volume = "114",

pages = "1273--1280",

journal = "Cardiovascular Research",

issn = "0008-6363",

publisher = "Oxford University Press",

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van der Velden, J, Tocchetti, CG, Varricchi, G, Bianco, A, Sequeira, V, Hilfiker-Kleiner, D, Hamdani, N, Leite-Moreira, AF, Mayr, M, Falcao-Pires, I, Thum, T, Dawson, DK, Balligand, J-L & Heymans, S 2018, 'Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology', Cardiovascular Research, vol. 114, no. 10, pp. 1273-1280. https://doi.org/10.1093/cvr/cvy147

Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. / van der Velden, Jolanda; Tocchetti, Carlo G.; Varricchi, Gilda et al.
In: Cardiovascular Research, Vol. 114, No. 10, 01.08.2018, p. 1273-1280.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

AU - van der Velden, Jolanda

AU - Tocchetti, Carlo G.

AU - Varricchi, Gilda

AU - Bianco, Anna

AU - Sequeira, Vasco

AU - Hilfiker-Kleiner, Denise

AU - Hamdani, Nazha

AU - Leite-Moreira, Adelino F.

AU - Mayr, Manuel

AU - Falcao-Pires, Ines

AU - Thum, Thomas

AU - Dawson, Dana K.

AU - Balligand, Jean-Luc

AU - Heymans, Stephane

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Disturbed metabolism as a consequence of obesity and diabetes may cause cardiac diseases (recently highlighted in the cardiovascular research spotlight issue on metabolic cardiomyopathies). 1 In turn, the metabolism of the heart may also be disturbed in genetic and acquired forms of hypertrophic cardiac disease. Herein, we provide an overview of recent insights on metabolic changes in genetic hypertrophic cardiomyopathy and discuss several therapies, which may be explored to target disturbed metabolism and prevent onset of cardiac hypertrophy.

AB - Disturbed metabolism as a consequence of obesity and diabetes may cause cardiac diseases (recently highlighted in the cardiovascular research spotlight issue on metabolic cardiomyopathies). 1 In turn, the metabolism of the heart may also be disturbed in genetic and acquired forms of hypertrophic cardiac disease. Herein, we provide an overview of recent insights on metabolic changes in genetic hypertrophic cardiomyopathy and discuss several therapies, which may be explored to target disturbed metabolism and prevent onset of cardiac hypertrophy.

KW - Hypertrophic cardiomyopathy

KW - Mutations

KW - Metabolism

KW - CARDIAC TROPONIN-T

KW - SPONTANEOUSLY HYPERTENSIVE-RAT

KW - LEFT-VENTRICULAR HYPERTROPHY

KW - SARCOMERIC GENE-MUTATIONS

KW - HEART-FAILURE

KW - NITRIC-OXIDE

KW - PERIPARTUM CARDIOMYOPATHY

KW - MICROVASCULAR DYSFUNCTION

KW - DIASTOLIC DYSFUNCTION

KW - ATRIAL-FIBRILLATION

U2 - 10.1093/cvr/cvy147

DO - 10.1093/cvr/cvy147

M3 - Article

C2 - 29912308

SN - 0008-6363

VL - 114

SP - 1273

EP - 1280

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 10

ER -

Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

Abstract

Keywords

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