Metabolic and genetic aspects of thiopurine metabolism

J.A. Bakker

Research output: ThesisDoctoral ThesisInternal

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Side-effects from drugs often have a genetic background. The described PhD research focuses on the causes of side-effects from certain anti-inflammatory drugs, the thiopurines. These are often used to treat (auto) immune diseases. In the case of thiopurine use it is important to determine the activity of the enzymes thiopurine-S-methyltransferase (TPMT) and inosine trifosfatase (ITPase) to prevent serious side-effects, such as bone marrow suppression and pneumonia and the involved hospitalisation. The research also shows that ITPase plays a role in the progression of pulmonary Langerhans’ cell histiocytosis (PLCH), a serious lung disease.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
  • Geraedts, Joep, Supervisor
  • Drent, Marjolein, Supervisor
  • Bierau, J., Co-Supervisor, External person
Award date27 Oct 2010
Place of PublicationMaastricht
Print ISBNs978 90 5278 975 0
Publication statusPublished - 1 Jan 2010


  • side-effects thiopurines
  • enzyme TPMT
  • enzyme ITPase

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