Metabolic adaptations to over-and underfeeding-still a matter of debate?

K.R. Westerterp

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Weight changes in response to a change in energy intake are smaller than calculated from the excess or deficit of energy intake. Digestion efficiency is not affected by intake level when consuming the same diet. Over- or underfeeding induces an increase or decrease in energy expenditure. Intake-induced expenditure changes are largely explained by proportional changes in diet-induced energy expenditure, in activity-induced energy expenditure and in maintenance expenditure as a function of changes in body weight and body composition. Additionally, underfeeding causes a metabolic adaptation as reflected in a reduction of maintenance expenditure below predicted values and defined as adaptive thermogenesis. Thus, alternating overfeeding and underfeeding with an iso-energetic amount results in a positive energy balance. The latter might be one of the explanations for the increasing incidence of obesity in our current society with an ample food supply.European Journal of Clinical Nutrition advance online publication, 12 December 2012; doi:10.1038/ejcn.2012.187.
Original languageEnglish
Pages (from-to)443-445
Number of pages3
JournalEuropean Journal of Clinical Nutrition
Volume67
Issue number5
DOIs
Publication statusPublished - May 2013

Keywords

  • energy balance
  • digestion efficiency
  • diet-induced energy expenditure
  • activity-induced energy expenditure
  • resting energy expenditure
  • VERTICAL BANDED GASTROPLASTY
  • RESTING ENERGY-EXPENDITURE
  • LIVING PHYSICAL-ACTIVITY
  • DOUBLY LABELED WATER
  • MASSIVE WEIGHT-LOSS
  • BODY-COMPOSITION
  • ADAPTIVE THERMOGENESIS
  • RESTRICTED DIET
  • OBESITY
  • FOOD

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