Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility

MooDS consortium; A. Reif

doi:10.1016/j.schres.2012.10.008

Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility

MooDS consortium, A. Reif

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17?10(-4), N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.

Original language	English
Pages (from-to)	200-205
Journal	Schizophrenia Research
Volume	142
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2012.10.008
Publication status	Published - Dec 2012

Keywords

VRK2
Schizophrenia
Asian populations
MRI
Brain imaging analysis

Access to Document

10.1016/j.schres.2012.10.008

Cite this

@article{43e7d80234234e60a728e6b7af8f4cb0,

title = "Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility",

abstract = "Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17?10(-4), N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.",

keywords = "VRK2, Schizophrenia, Asian populations, MRI, Brain imaging analysis",

author = "Ming Li and Yi Wang and Xue-bin Zheng and Masashi Ikeda and Nakao Iwata and Xiong-jian Luo and Chong, {Siow Ann} and Jimmy Lee and Marcella Rietschel and Fengyu Zhang and Bertram Mueller-Myhsok and Sven Cichon and Weinberger, {Daniel R.} and Manuel Mattheisen and Schulze, {Thomas G.} and Martin, {Nicholas G.} and Mitchell, {Philip B.} and Schofield, {Peter R.} and Jian-jun Liu and {MooDS consortium} and A. Reif and Bing Su",

year = "2012",

month = dec,

doi = "10.1016/j.schres.2012.10.008",

language = "English",

volume = "142",

pages = "200--205",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier Science",

number = "1-3",

}

TY - JOUR

T1 - Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility

AU - Li, Ming

AU - Wang, Yi

AU - Zheng, Xue-bin

AU - Ikeda, Masashi

AU - Iwata, Nakao

AU - Luo, Xiong-jian

AU - Chong, Siow Ann

AU - Lee, Jimmy

AU - Rietschel, Marcella

AU - Zhang, Fengyu

AU - Mueller-Myhsok, Bertram

AU - Cichon, Sven

AU - Weinberger, Daniel R.

AU - Mattheisen, Manuel

AU - Schulze, Thomas G.

AU - Martin, Nicholas G.

AU - Mitchell, Philip B.

AU - Schofield, Peter R.

AU - Liu, Jian-jun

AU - MooDS consortium

AU - Reif, A.

AU - Su, Bing

PY - 2012/12

Y1 - 2012/12

N2 - Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17?10(-4), N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.

AB - Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17?10(-4), N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.

KW - VRK2

KW - Schizophrenia

KW - Asian populations

KW - MRI

KW - Brain imaging analysis

U2 - 10.1016/j.schres.2012.10.008

DO - 10.1016/j.schres.2012.10.008

M3 - Article

C2 - 23102693

SN - 0920-9964

VL - 142

SP - 200

EP - 205

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-3

ER -