Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility

MooDS consortium, A. Reif

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Web of Science)

Abstract

Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17?10(-4), N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.
Original languageEnglish
Pages (from-to)200-205
JournalSchizophrenia Research
Volume142
Issue number1-3
DOIs
Publication statusPublished - Dec 2012

Keywords

  • VRK2
  • Schizophrenia
  • Asian populations
  • MRI
  • Brain imaging analysis

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