Message in a Microbottle: Modulation of Vascular Inflammation and Atherosclerosis by Extracellular Vesicles

Emiel P. C. van der Vorst; Renske J. de Jong; Marjo M. P. C. Donners

doi:10.3389/fcvm.2018.00002

Message in a Microbottle: Modulation of Vascular Inflammation and Atherosclerosis by Extracellular Vesicles

Emiel P. C. van der Vorst^*, Renske J. de Jong, Marjo M. P. C. Donners^*

^*Corresponding author for this work

Pathologie

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Extracellular vesicles (EVs) have emerged as a novel intercellular communication system. By carrying bioactive lipids, miRNAs and proteins they can modulate target cell functions and phenotype. Circulating levels of EVs are increased in inflammatory conditions, e.g., cardiovascular disease patients, and their functional contribution to atherosclerotic disease development is currently heavily studied. This review will describe how EVs can modulate vascular cell functions relevant to vascular inflammation and atherosclerosis, particularly highlighting the role of EV-associated proteolytic activity and effector proteins involved. Furthermore, we will discuss key questions and challenges, especially for EV-based therapeutics.

Original language	English
Article number	2
Number of pages	8
Journal	Frontiers in Cardiovascular Medicine
Volume	5
DOIs	https://doi.org/10.3389/fcvm.2018.00002
Publication status	Published - 22 Jan 2018

Keywords

extracellular vesicles
vascular inflammation
atherosclerosis
proteolytic activity
challenges
CELL-DERIVED MICROPARTICLES
SMOOTH-MUSCLE-CELLS
CORONARY-ARTERY-DISEASE
ENDOTHELIAL MICROPARTICLES
PLATELET MICROPARTICLES
IN-VITRO
EXOSOMES
MICROVESICLES
PLAQUES
CALCIFICATION

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10.3389/fcvm.2018.00002Licence: CC BY

https://www.frontiersin.org/articles/10.3389/fcvm.2018.00002/pdf

Cite this

@article{29f707370bf14335b4e681366adb55d9,

title = "Message in a Microbottle: Modulation of Vascular Inflammation and Atherosclerosis by Extracellular Vesicles",

abstract = "Extracellular vesicles (EVs) have emerged as a novel intercellular communication system. By carrying bioactive lipids, miRNAs and proteins they can modulate target cell functions and phenotype. Circulating levels of EVs are increased in inflammatory conditions, e.g., cardiovascular disease patients, and their functional contribution to atherosclerotic disease development is currently heavily studied. This review will describe how EVs can modulate vascular cell functions relevant to vascular inflammation and atherosclerosis, particularly highlighting the role of EV-associated proteolytic activity and effector proteins involved. Furthermore, we will discuss key questions and challenges, especially for EV-based therapeutics.",

keywords = "extracellular vesicles, vascular inflammation, atherosclerosis, proteolytic activity, challenges, CELL-DERIVED MICROPARTICLES, SMOOTH-MUSCLE-CELLS, CORONARY-ARTERY-DISEASE, ENDOTHELIAL MICROPARTICLES, PLATELET MICROPARTICLES, IN-VITRO, EXOSOMES, MICROVESICLES, PLAQUES, CALCIFICATION",

author = "{van der Vorst}, {Emiel P. C.} and {de Jong}, {Renske J.} and Donners, {Marjo M. P. C.}",

year = "2018",

month = jan,

day = "22",

doi = "10.3389/fcvm.2018.00002",

language = "English",

volume = "5",

journal = "Frontiers in Cardiovascular Medicine",

issn = "2297-055X",

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TY - JOUR

T1 - Message in a Microbottle: Modulation of Vascular Inflammation and Atherosclerosis by Extracellular Vesicles

AU - van der Vorst, Emiel P. C.

AU - de Jong, Renske J.

AU - Donners, Marjo M. P. C.

PY - 2018/1/22

Y1 - 2018/1/22

N2 - Extracellular vesicles (EVs) have emerged as a novel intercellular communication system. By carrying bioactive lipids, miRNAs and proteins they can modulate target cell functions and phenotype. Circulating levels of EVs are increased in inflammatory conditions, e.g., cardiovascular disease patients, and their functional contribution to atherosclerotic disease development is currently heavily studied. This review will describe how EVs can modulate vascular cell functions relevant to vascular inflammation and atherosclerosis, particularly highlighting the role of EV-associated proteolytic activity and effector proteins involved. Furthermore, we will discuss key questions and challenges, especially for EV-based therapeutics.

AB - Extracellular vesicles (EVs) have emerged as a novel intercellular communication system. By carrying bioactive lipids, miRNAs and proteins they can modulate target cell functions and phenotype. Circulating levels of EVs are increased in inflammatory conditions, e.g., cardiovascular disease patients, and their functional contribution to atherosclerotic disease development is currently heavily studied. This review will describe how EVs can modulate vascular cell functions relevant to vascular inflammation and atherosclerosis, particularly highlighting the role of EV-associated proteolytic activity and effector proteins involved. Furthermore, we will discuss key questions and challenges, especially for EV-based therapeutics.

KW - extracellular vesicles

KW - vascular inflammation

KW - atherosclerosis

KW - proteolytic activity

KW - challenges

KW - CELL-DERIVED MICROPARTICLES

KW - SMOOTH-MUSCLE-CELLS

KW - CORONARY-ARTERY-DISEASE

KW - ENDOTHELIAL MICROPARTICLES

KW - PLATELET MICROPARTICLES

KW - IN-VITRO

KW - EXOSOMES

KW - MICROVESICLES

KW - PLAQUES

KW - CALCIFICATION

U2 - 10.3389/fcvm.2018.00002

DO - 10.3389/fcvm.2018.00002

M3 - (Systematic) Review article

SN - 2297-055X

VL - 5

JO - Frontiers in Cardiovascular Medicine

JF - Frontiers in Cardiovascular Medicine

M1 - 2

ER -