Mental pain as a global person-centered outcome measure

Fiammetta Cosci*, Giovanni Mansueto, Silvia Benemei, Alberto Chiarugi, Francesco De Cesaris, Tom Sensky

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND: Mental pain has been proposed as a global person-centered outcome measure. The aim of this cross-sectional study was to test an essential requisite of such a measure, namely that mental pain incorporates independent contributions from a range of discrete but disparate outcome measures.

METHODS: Two hundred migraine patients were assessed concerning migraine disability, psychosomatic syndromes, mental pain, depression, anxiety, and psychosocial dimensions. General linear models were tested to verify which measures would individually make unique contributions to overall mental pain.

RESULTS: The final model, accounting for 44% of variance, identified that higher mental pain was associated with more severe depressive symptoms, higher migraine disability, lower well-being, and poorer quality of life.

CONCLUSION: In this sample, mental pain was shown to behave as expected of a global outcome measure, since multiple measures of symptomatology and quality of life showed modest but significant bivariate correlations with mental pain and some of these measures individually made unique contributions to overall mental pain.

Original languageEnglish
Article number1092852921000699
Pages (from-to)652-658
Number of pages7
JournalCns Spectrums
Issue number5
Early online date27 Jul 2021
Publication statusPublished - Oct 2022


  • CARE
  • Mental pain
  • global person-centered outcome measure
  • migraine
  • psychic pain
  • psychological pain
  • suffering


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