Menopausal hormone use and ovarian cancer risk: individual participant meta-analysis of 52 epidemiological studies

L.J. Schouten, P.A. van den Brandt, the Collaborative Group on Epidemiological Studies of Ovarian Cancer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background Half the epidemiological studies with information about menopausal hormone therapy and ovarian cancer risk remain unpublished, and some retrospective studies could have been biased by selective participation or recall. We aimed to assess with minimal bias the effects of hormone therapy on ovarian cancer risk. Methods Individual participant datasets from 52 epidemiological studies were analysed centrally. The principal analyses involved the prospective studies (with last hormone therapy use extrapolated forwards for up to 4 years). Sensitivity analyses included the retrospective studies. Adjusted Poisson regressions yielded relative risks (RRs) versus never-use. Findings During prospective follow-up, 12 110 postmenopausal women, 55% (6601) of whom had used hormone therapy, developed ovarian cancer. Among women last recorded as current users, risk was increased even with
Original languageEnglish
Pages (from-to)1835-1842
JournalLancet
Volume385
Issue number9980
DOIs
Publication statusPublished - 1 Jan 2015

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