Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers

Linda Kachuri, Olli Saarela, Stig Egil Bojesen, George Davey Smith, Geoffrey Liu, Maria Teresa Landi, Neil E. Caporaso, David C. Christiani, Mattias Johansson, Salvatore Panico, Kim Overvad, Antonia Trichopoulou, Paolo Vineis, Ghislaine Scelo, David Zaridze, Xifeng Wu, Demetrius Albanes, Brenda Diergaarde, Pagona Lagiou, Gary J. MacfarlaneMelinda C. Aldrich, Adonina Tardon, Gad Rennert, Andrew F. Olshan, Mark C. Weissler, Chu Chen, Gary E. Goodman, Jennifer A. Doherty, Andrew R. Ness, Heike Bickeboeller, H-Erich Wichmann, Angela Risch, John K. Field, M. Dawn Teare, Lambertus A. Kiemeney, Erik H. F. M. van der Heijden, June C. Carroll, Aage Haugen, Shanbeh Zienolddiny, Vidar Skaug, Victor Wunsch-Filho, Eloiza H. Tajara, Raquel Ayoub Moyses, Fabio Daumas Nunes, Stephen Lam, Jose Eluf-Neto, Martin Lacko, Wilbert H. M. Peters, Loic Le Marchand, Eric J. Duell, Angeline S. Andrew, Silvia Franceschi, Matthew B. Schabath, Jonas Manjer, Susanne Arnold, Philip Lazarus, Anush Mukeriya, Beata Swiatkowska, Vladimir Janout, Ivana Holcatova, Jelena Stojsic, Dana Mates, Jolanta Lissowska, Stefania Boccia, Corina Lesseur, Xuchen Zong, James D. McKay, Paul Brennan, Christopher I. Amos, Rayjean J. Hung*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)751-766
Number of pages16
JournalInternational Journal of Epidemiology
Volume48
Issue number3
DOIs
Publication statusPublished - Jun 2019

Keywords

  • lung cancer
  • telomere length
  • chromosome 5p15.33
  • Mendelian Randomization
  • mediation analysis
  • TERT
  • GENOME-WIDE ASSOCIATION
  • SUSCEPTIBILITY LOCI
  • GENETIC-VARIANTS
  • NEVER SMOKERS
  • DYSFUNCTION
  • IDENTIFICATION
  • EPIDEMIOLOGY
  • METAANALYSIS
  • CHALLENGES
  • EXTENSION

Cite this

Kachuri, L., Saarela, O., Bojesen, S. E., Smith, G. D., Liu, G., Landi, M. T., Caporaso, N. E., Christiani, D. C., Johansson, M., Panico, S., Overvad, K., Trichopoulou, A., Vineis, P., Scelo, G., Zaridze, D., Wu, X., Albanes, D., Diergaarde, B., Lagiou, P., ... Hung, R. J. (2019). Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers. International Journal of Epidemiology, 48(3), 751-766. https://doi.org/10.1093/ije/dyy140