Memory in humans is unaffected by central H1-antagonism, while objectively and subjectively measured sedation is increased

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Abstract

Animal literature suggests an important role for histamine in memory. In humans, this hypothesis has been scarcely tested and results from studies that have addressed this are conflicting. Second, impaired memory performance may be secondary to sedation. This study aimed to determine whether a centrally active antihistamine impairs memory performance and to dissociate such effects from sedation. Eighteen healthy volunteers received single oral doses of dexchlorpheniramine 4 mg, lorazepam 1mg and placebo in a 3-way, double blind, crossover designed study. The active control lorazepam impaired episodic- and working memory performance and increased sedation, while dexchlorpheniramine only increased sedation.
Original languageEnglish
Pages (from-to)226-235
Number of pages10
JournalEuropean Neuropsychopharmacology
Volume20
Issue number4
DOIs
Publication statusPublished - Apr 2010

Keywords

  • Antihistamines
  • Benzodiazepines
  • COGNITION
  • Cognition
  • Event related potentials
  • HEALTHY-VOLUNTEERS
  • HISTAMINE H-3 RECEPTOR
  • HUMAN BRAIN
  • LORAZEPAM
  • Memory
  • PLACEBO
  • PSYCHOMETRIC TEST-PERFORMANCE
  • PSYCHOMOTOR PERFORMANCE
  • SCOPOLAMINE
  • Sedation
  • WORKING-MEMORY

Cite this

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title = "Memory in humans is unaffected by central H1-antagonism, while objectively and subjectively measured sedation is increased",
abstract = "Animal literature suggests an important role for histamine in memory. In humans, this hypothesis has been scarcely tested and results from studies that have addressed this are conflicting. Second, impaired memory performance may be secondary to sedation. This study aimed to determine whether a centrally active antihistamine impairs memory performance and to dissociate such effects from sedation. Eighteen healthy volunteers received single oral doses of dexchlorpheniramine 4 mg, lorazepam 1mg and placebo in a 3-way, double blind, crossover designed study. The active control lorazepam impaired episodic- and working memory performance and increased sedation, while dexchlorpheniramine only increased sedation.",
keywords = "Antihistamines, Benzodiazepines, COGNITION, Cognition, Event related potentials, HEALTHY-VOLUNTEERS, HISTAMINE H-3 RECEPTOR, HUMAN BRAIN, LORAZEPAM, Memory, PLACEBO, PSYCHOMETRIC TEST-PERFORMANCE, PSYCHOMOTOR PERFORMANCE, SCOPOLAMINE, Sedation, WORKING-MEMORY",
author = "{van Ruitenbeek}, P. and A. Vermeeren and W.J. Riedel",
year = "2010",
month = "4",
doi = "10.1016/j.euroneuro.2009.12.003",
language = "English",
volume = "20",
pages = "226--235",
journal = "European Neuropsychopharmacology",
issn = "0924-977X",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Memory in humans is unaffected by central H1-antagonism, while objectively and subjectively measured sedation is increased

AU - van Ruitenbeek, P.

AU - Vermeeren, A.

AU - Riedel, W.J.

PY - 2010/4

Y1 - 2010/4

N2 - Animal literature suggests an important role for histamine in memory. In humans, this hypothesis has been scarcely tested and results from studies that have addressed this are conflicting. Second, impaired memory performance may be secondary to sedation. This study aimed to determine whether a centrally active antihistamine impairs memory performance and to dissociate such effects from sedation. Eighteen healthy volunteers received single oral doses of dexchlorpheniramine 4 mg, lorazepam 1mg and placebo in a 3-way, double blind, crossover designed study. The active control lorazepam impaired episodic- and working memory performance and increased sedation, while dexchlorpheniramine only increased sedation.

AB - Animal literature suggests an important role for histamine in memory. In humans, this hypothesis has been scarcely tested and results from studies that have addressed this are conflicting. Second, impaired memory performance may be secondary to sedation. This study aimed to determine whether a centrally active antihistamine impairs memory performance and to dissociate such effects from sedation. Eighteen healthy volunteers received single oral doses of dexchlorpheniramine 4 mg, lorazepam 1mg and placebo in a 3-way, double blind, crossover designed study. The active control lorazepam impaired episodic- and working memory performance and increased sedation, while dexchlorpheniramine only increased sedation.

KW - Antihistamines

KW - Benzodiazepines

KW - COGNITION

KW - Cognition

KW - Event related potentials

KW - HEALTHY-VOLUNTEERS

KW - HISTAMINE H-3 RECEPTOR

KW - HUMAN BRAIN

KW - LORAZEPAM

KW - Memory

KW - PLACEBO

KW - PSYCHOMETRIC TEST-PERFORMANCE

KW - PSYCHOMOTOR PERFORMANCE

KW - SCOPOLAMINE

KW - Sedation

KW - WORKING-MEMORY

U2 - 10.1016/j.euroneuro.2009.12.003

DO - 10.1016/j.euroneuro.2009.12.003

M3 - Article

VL - 20

SP - 226

EP - 235

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

SN - 0924-977X

IS - 4

ER -